Lys-Nε-SPDB-DM4 - CAS 1280215-91-9
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Lys-Nε-SPDB-DM4 - CAS 1280215-91-9 Catalog number: BADC-01467

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Lys-Nε-SPDB-DM4 is a drug-linker conjugate consisting of the potent tubulin inhibitor DM4 and the linker Lys-Nε-SPDB for the preparation of antibody-drug conjugates (ADCs).

Category
ADCs Cytotoxin
Product Name
Lys-Nε-SPDB-DM4
CAS
1280215-91-9
Catalog Number
BADC-01467
Molecular Formula
C48H72ClN5O13S2
Molecular Weight
1026.69
Lys-Nε-SPDB-DM4

Ordering Information

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BADC-01467 -- $--
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Description
Lys-Nε-SPDB-DM4 is a drug-linker conjugate consisting of the potent tubulin inhibitor DM4 and the linker Lys-Nε-SPDB for the preparation of antibody-drug conjugates (ADCs).
Synonyms
DM4-spdb-L-lysine; Lys-Nepsilon-SPDB-DM4
IUPAC Name
(2S)-2-amino-6-[4-[[5-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-2-methyl-5-oxopentan-2-yl]disulfanyl]butanoylamino]hexanoic acid
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCC(C)(C)SSCCCC(=O)NCCCCC(C(=O)O)N)C)C)OC)(NC(=O)O2)O
InChI
InChI=1S/C48H72ClN5O13S2/c1-28-15-13-17-36(64-10)48(62)27-35(65-45(61)52-48)29(2)42-47(6,67-42)37(26-40(57)54(8)33-24-31(23-28)25-34(63-9)41(33)49)66-44(60)30(3)53(7)39(56)19-20-46(4,5)69-68-22-14-18-38(55)51-21-12-11-16-32(50)43(58)59/h13,15,17,24-25,29-30,32,35-37,42,62H,11-12,14,16,18-23,26-27,50H2,1-10H3,(H,51,55)(H,52,61)(H,58,59)/b17-13+,28-15+/t29-,30+,32+,35+,36-,37+,42+,47+,48+/m1/s1
InChIKey
VUAUZOXSQKWNNO-NBSRGMMNSA-N
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: DBCO-PEG4-HyNic | Lys-Nε-SPDB-DM4
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