Taltobulin hydrochloride

Taltobulin hydrochloride Catalog number: BADC-01381

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Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic tripeptide cysteine analog, Taltobulin is a potent antimicrotubule that circumvents P-glycoprotein-mediated drug resistance in vitro and in vivo sex. Taltobulin hydrochloride inhibits purified tubulin polymerization, disrupts microtubule organization in cells, and induces mitotic arrest and apoptosis.

Category
ADCs Cytotoxin
Product Name
Taltobulin hydrochloride
Catalog Number
BADC-01381
Molecular Formula
C27H44ClN3O4
Molecular Weight
510.11
Taltobulin hydrochloride

Ordering Information

Catalog Number Size Price Quantity
BADC-01381 -- $--
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Description
Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic tripeptide cysteine analog, Taltobulin is a potent antimicrotubule that circumvents P-glycoprotein-mediated drug resistance in vitro and in vivo sex. Taltobulin hydrochloride inhibits purified tubulin polymerization, disrupts microtubule organization in cells, and induces mitotic arrest and apoptosis.
Synonyms
HTI-286 hydrochloride; SPA-110 hydrochloride
IUPAC Name
(E,4S)-4-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(methylamino)-3-phenylbutanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid;hydrochloride
Canonical SMILES
CC(C)C(C=C(C)C(=O)O)N(C)C(=O)C(C(C)(C)C)NC(=O)C(C(C)(C)C1=CC=CC=C1)NC.Cl
InChI
InChI=1S/C27H43N3O4.ClH/c1-17(2)20(16-18(3)25(33)34)30(10)24(32)22(26(4,5)6)29-23(31)21(28-9)27(7,8)19-14-12-11-13-15-19;/h11-17,20-22,28H,1-10H3,(H,29,31)(H,33,34);1H/b18-16+;/t20-,21-,22-;/m1./s1
InChIKey
UBHYRJPUQWUXCX-LPWSJWOVSA-N
Appearance
Solid
Purity
98.34%
Storage
Store at 0-4°C for short term (days to weeks) or -20°C for long term (months to years), away from moisture
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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