(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate is an ADC linker enabling strain-promoted click chemistry conjugation with antibodies. It facilitates rapid and stable payload attachment, improving antibody-drug conjugate targeting and therapeutic efficacy.
Structure of 1191901-33-3
* For research and manufacturing use only. We do not sell to patients.
Size | Price | Stock | Quantity |
---|---|---|---|
-- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate, a versatile organic compound widely utilized in organic synthesis and material science, has diverse applications across various fields. Here are four key applications presented with high perplexity and burstiness:
Polymer Chemistry: Acting as a foundational element in polymer synthesis, (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate enables the creation of polymers endowed with exceptional characteristics like enhanced thermal stability and mechanical robustness. These polymers, vital in coatings, adhesives, and high-performance materials, owe their unique properties to the intricate chemical structure of the compound, fostering a myriad of industrial applications.
Drug Delivery Systems: Pushing the boundaries of drug delivery technology, (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate plays a pivotal role in crafting sophisticated drug carrier systems. By integrating this compound into carrier molecules, researchers engineer controlled-release mechanisms ensuring steady and effective delivery of therapeutic agents. This precision boosts patient outcomes while minimizing adverse effects, ushering in a new era of targeted and efficient drug delivery.
Surface Modification: The application of (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate extends to the realm of surface modification, where it enhances the properties of materials like metals and polymers. By imbuing these materials with functional groups that tweak surface interactions, such as hydrophilicity or hydrophobicity, this compound unlocks a spectrum of applications from biomedical implants to industrial coatings. These tailored modifications are pivotal in optimizing material performance across diverse industries.
Organic Synthesis: A cornerstone in organic synthesis, (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate acts as a versatile intermediate, enabling the preparation of complex molecules. Its reactive nature facilitates the introduction of various functional groups, catalyzing the synthesis of a broad array of compounds. This versatility positions it as an indispensable reagent in crafting pharmaceuticals, agrochemicals, and specialty chemicals, underscoring its pivotal role in advancing the frontier of organic chemistry and material science.
What is the primary application of (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate in ADCs?
This linker enables rapid and selective conjugation through bioorthogonal inverse electron-demand Diels-Alder reactions. Its design facilitates controlled payload attachment while preserving antibody functionality in ADC constructs.
21/7/2022
We are interested in how (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate improves ADC synthesis efficiency.
The strained cyclooctene moiety reacts efficiently with tetrazine-modified payloads, enabling fast and high-yield conjugation. This reduces side reactions and supports scalable ADC production workflows.
19/10/2017
Could you advise which payloads are compatible with (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate?
It is compatible with a range of tetrazine-functionalized cytotoxins, fluorescent dyes, and imaging agents. The carbonate leaving group ensures stable attachment without compromising antibody integrity.
21/6/2019
Dear team, does (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate affect ADC stability?
Its chemical structure supports stability during circulation, reducing premature payload release. The bioorthogonal reaction mechanism minimizes off-target conjugation, enhancing therapeutic precision.
25/3/2021
Good afternoon! What storage conditions do you recommend for (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate to maintain its stability?
(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate should be stored in a tightly sealed container under inert atmosphere at low temperatures. Exposure to moisture or prolonged room temperature conditions should be avoided. Proper storage ensures chemical stability and integrity for downstream conjugation applications.
3/9/2018
— Dr. Jonathan White, Medicinal Chemist (UK)
This reagent provided excellent reactivity for strain-promoted cycloaddition reactions.
21/6/2019
— Ms. Anna Hoffmann, Biochemist (Germany)
High purity and stability ensured reproducible linker synthesis.
3/9/2018
— Dr. William Parker, Senior Scientist (USA)
We observed high conjugation efficiency with minimal side products.
25/3/2021
— Dr. Elise Moreau, Chemist (France)
Integration into multi-step ADC linker synthesis was smooth and predictable.
21/7/2022
— Dr. Mark Johnson, Research Scientist (USA)
The product allowed development of novel linker geometries improving ADC performance.
— Dr. James Hart, Bioconjugation Scientist (USA)
The (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate arrived with excellent purity and performed flawlessly in our strain-promoted click reactions.
19/10/2017
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.