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DM4-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). .
DM4-SMe, a potent cytotoxic agent utilized primarily in the realm of targeted cancer therapies, exhibits a range of applications with high perplexity and burstiness:
Antibody-Drug Conjugates (ADCs): Partnering with antibodies tailored to pinpoint cancer cells, DM4-SMe forms antibody-drug conjugates, delivering the cytotoxic payload specifically to malignant cells while sparing healthy tissues. This precision targeting strategy amplifies treatment efficacy while minimizing systemic toxicity, marking a significant advancement in cancer therapy.
Cancer Research: Within preclinical investigations, DM4-SMe serves as a pivotal tool for delving into the mechanisms of action and therapeutic potentials of novel cancer treatments. Researchers leverage DM4-SMe in assessing the efficacy, safety, and pharmacokinetics of therapies linked to it across diverse cancer models, furnishing essential insights crucial for propelling potential treatments towards clinical trials.
Toxin-based Drug Development: Serving as a foundational platform for crafting cutting-edge cytotoxic compounds with enhanced attributes, DM4-SMe undergoes structural modifications to yield derivatives boasting heightened potency, stability, or tumor-targeting abilities. This iterative process of refinement propels the evolution of more potent and target-specific cancer therapeutics, driving innovation in the field.
Cell Line Development: Instrumental in establishing resilient cancer cell lines for both drug screening and resistance mechanism exploration, DM4-SMe is employed to cultivate cells resistant to its cytotoxic effects. These resistant cells serve as valuable models for dissecting resistance pathways and identifying biomarkers, enlightening researchers on the mechanisms underlying therapeutic resistance and aiding in the design of next-generation anticancer drugs.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
