Maytansinoid DM4 - CAS 799840-96-3

Maytansinoid DM4 - CAS 799840-96-3 Catalog number: BADC-00087

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DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.

Category
ADCs Cytotoxin
Product Name
Maytansinoid DM4
CAS
799840-96-3
Catalog Number
BADC-00087
Molecular Formula
C39H56ClN3O10S
Molecular Weight
780.37
Maytansinoid DM4

Ordering Information

Catalog Number Size Price Quantity
BADC-00087 -- $--
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Description
DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
Synonyms
N2'-deacetyl-n2'-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine
IUPAC Name
[(1S,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,2,5,9,16-pentamethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl-(4-methyl-4-sulfanylpentanoyl)amino]propanoate
Canonical SMILES
CC1=CC=CC(C2(CC(C(C3C(O3)(C(CC(=O)N(C4=C(C(=CC(=C4)C1)OC)Cl)C)OC(=O)C(C)N(C)C(=O)CCC(C)(C)S)C)(C)C)OC(=O)N2)O)OC
InChI
InChI=1S/C39H56ClN3O10S/c1-22-13-12-14-27(50-11)39(48)21-29(52-35(47)41-39)37(5,6)34-38(7,53-34)28(51-33(46)23(2)42(8)30(44)15-16-36(3,4)54)20-31(45)43(9)25-18-24(17-22)19-26(49-10)32(25)40/h12-14,18-19,23,27-29,34,48,54H,15-17,20-21H2,1-11H3,(H,41,47)/b14-12+,22-13+/t23-,27+,28-,29-,34-,38-,39-/m0/s1
InChIKey
SVVGCFZPFZGWRG-OTKBOCOUSA-N
Density
1.3±0.1 g/cm3
Solubility
Soluble in DMSO, chloroform (slightly), methanol (slightly)
Flash Point
522.4±34.3 °C
Index Of Refraction
1.587
LogP
6.26
Vapor Pressure
0.0±0.3 mmHg at 25°C
Clinical Trial Information
NCT NumberCondition Or DiseasePhaseStart DateSponsorStatus
NCT03045393Breast Cancer Triple NegativePhase 12018-07-05Duke UniversityWithdrawn (Inadequate enrollment)
NCT04606914Ovarian CancerPhase 22021-07-08University of Alabama at BirminghamRecruiting
NCT05041257Ovarian CancerPhase 22021-09-22ImmunoGen, Inc.Recruiting
NCT03455556Mesothelin PositivePhase 12020-05-15Mayo ClinicTerminated (slow accrual)
NCT00352131Non-colorectal CancerPhase 12010-03-17ImmunoGen, Inc.Completed
Application
ADCs Cytotoxin
Appearance
White to off-white solid
Purity
≥98.0% (HPLC)
Quantity
Milligrams-Grams
Shipping
Room temperature
Storage
Hygroscopic, -20°C Freezer, Under inert atmosphere
Boiling Point
940.2±65.0 °C at 760 mmHg

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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