DM3 - CAS 796073-54-6

DM3 - CAS 796073-54-6 Catalog number: BADC-00339

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DM3 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.

Category
ADCs Cytotoxin
Product Name
DM3
CAS
796073-54-6
Catalog Number
BADC-00339
Molecular Formula
C37H52ClN3O10S
Molecular Weight
766.34
DM3

Ordering Information

Catalog Number Size Price Quantity
BADC-00339 5 mg $729
BADC-00339 25 mg $1573
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Description
DM3 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
Synonyms
N2'-deacetyl-N2'-(4-mercapto-1-oxopentyl)- maytansine;
IUPAC Name
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(4-sulfanylpentanoyl)amino]propanoate
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCC(C)S)C)C)OC)(NC(=O)O2)O
InChI
InChI=1S/C37H52ClN3O10S/c1-20-11-10-12-28(48-9)37(46)19-27(49-35(45)39-37)22(3)33-36(5,51-33)29(50-34(44)23(4)40(6)30(42)14-13-21(2)52)18-31(43)41(7)25-16-24(15-20)17-26(47-8)32(25)38/h10-12,16-17,21-23,27-29,33,46,52H,13-15,18-19H2,1-9H3,(H,39,45)/b12-10+,20-11+/t21?,22-,23+,27+,28-,29+,33+,36+,37+/m1/s1
InChIKey
LJFFDOBFKICLHN-IXWHRVGISA-N
In Vitro
DM3 altered the expression of competence-induction pathways by upregulating CelA, CelB, and CglA while downregulating Ccs16, ComF, and Ccs4 proteins. Capsular polysaccharide subunits were downregulated in DM3-treated cells, however, it was upregulated in PEN- and DM3PEN-treated groups. Additionally, DM3 altered the amino acids biosynthesis pathways, particularly targeting ribosomal rRNA subunits. Downregulation of cationic AMPs resistance pathway suggests that DM3 treatment could autoenhance pneumococci susceptibility to DM3. Gene enrichment analysis showed that unlike PEN and DM3PEN, DM3 treatment exerted no effect on DNA-binding RNA polymerase activity but observed downregulation of RpoD and RNA polymerase sigma factor.
Appearance
Soild powder
Purity
≥95%
Shipping
Room temperature
1. Lung function in divers
E Prokop, R Klos, M Konarski, K Korzeniewski, Aneta Nitsch-Osuch Adv Exp Med Biol . 2013;788:221-7. doi: 10.1007/978-94-007-6627-3_32.
Correct lung function is indispensible to perform work underwater. Thus, spirometric tests of lung function remain an important element in the process of selecting candidates for professional diving. Studies conducted in the population of divers identified the phenomenon called 'large lungs', which is often associated with spirometric indices characteristic of obstructive impairment of lung function. This study investigated selected parameters of lung function in the population of divers and candidates for professional divers. Fifty two male subjects were examined as part of the selection process. Basic spirometric tests: forced expiratory volume in 1 s (FEV1; dm(3)), forced vital capacity (FVC; dm(3)), forced expiratory flow in the range 25-75 % of FVC (FEF25-75; dm(3) s(-1)), and FEV1/FVC (%) were compared with compared with the predicted reference values estimated by the European Coal and Steel Community. The results demonstrate differences in FVC and FEF25-75 in divers, which may correspond to functional hyperinflation. The effects of 'large lungs' observed in divers, if persisting for an extended period of time, may lead to lung ventilation impairment of the obstructive type.
2. Electrodeposition of indium from non-aqueous electrolytes
Clio Deferm, Jan Fransaer, Koen Binnemans, Wouter Monnens, Jeroen Sniekers Chem Commun (Camb) . 2019 Apr 18;55(33):4789-4792. doi: 10.1039/c8cc10254f.
The electrochemical behaviour and deposition of indium in electrolytes composed of 0.4 mol dm-3 In(Tf2N)3 and 0.4 mol dm-3 InCl3 in the solvents 1,2-dimethoxyethane and poly(ethylene glycol) (average molecular mass of 0.400 kg mol-1, PEG400) was investigated. Indium(i) was identified as the intermediate species that disproportionated to indium(iii) and indium(0) nanoparticles. The presence of nanoparticles was verified by TEM analysis. SEM analysis showed that deposits obtained at room temperature from 1,2-dimethoxyethane were rough, while spherical structures were formed in PEG400 at 160 °C.
3. Bean and chia development in accordance with fertilization management
Tiago Roque Benetoli da Silva, Debora Fernandes Del Moura Soares, Gessica Daiane da Silva, Rhaizza Lana Pereira Ducheski, Jaqueline Calzavara Bordin-Rodrigues, Juliana Stracieri Heliyon . 2021 Jun 12;7(6):e07316. doi: 10.1016/j.heliyon.2021.e07316.
Chia seed is expanding on the market due to its characteristics, but there are few studies on its response to residual fertilization of other crops. The objective was to evaluate the vegetative and productive parameters of common bean as a function of the base fertilization increment and to verify the influence of the residue of this fertilization on the development of chia. The experiment was carried out in two stages, Maringá State University, Umuarama Regional Campus, in a randomized block design with 4 replications. The treatments for the first stage were: T1 - doses recommended for beans and T2, T3, T4 and T5, were recommended doses for beans with increments for each treatment. The evaluated variables were: shoot dry matter, number of pods per plant, grains per plant, grains per pod, 1000 grains weight and yield. In the second stage, the experiment was installed in the same place of the previous cultivation. The treatments were: residual bean fertilization, T6 - plus the treatment with the recommendation for chia. The evaluated variables were: macro and micronutrient leaf contents, shoot dry matter, final plant population, 1.000 grains weight, oil content and yield. For beans and chia, soil samples were collected after harvest to evaluate chemical attributes. In common bean, the results were not significant in the evaluated parameters. In soil, the residual effect of beans was significant for P and K, with 27.2 mg dm-3and 167.70 mg dm-3, in treatment T5 and chia was 23.1 mg dm-3and 89.7 mg dm-3, for treatment T6, respectively. In chia, yield, oil content and P for leaf macro and micronutrient leaf contents were significant. Thus, the vegetative and productive parameters of the common bean were not influenced by the increase in fertilization. The residual effect was higher for P and K, for beans and chia. For chia, influences by residual effect were observed.
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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