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CAS No.: 225780-77-8
Cat No.: BADC-01950
4.5 
3-Azido-N-Boc-D-Alanine is a bioorthogonal conjugation building block that provides an azide handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is azide bioorthogonal handle; requires complementary click handle on the antibody. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.
Structure of 225780-77-8
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3-Azido-N-Boc-D-Alanine, a versatile chemical compound with diverse applications in biochemical and pharmaceutical research, showcases high perplexity and burstiness in its key applications:
Peptide Synthesis: Widely integrated into peptide synthesis, 3-Azido-N-Boc-D-Alanine acts as a pivotal building block in solid-phase synthesis, enabling the introduction of azido functional groups. This is crucial for applications of click chemistry, where azide-alkyne cycloaddition is employed to connect peptide chains through varied lengths, contributing to the multifaceted complexity of peptide structures and functionality.
Drug Discovery: Within the realm of pharmaceutical research, 3-Azido-N-Boc-D-Alanine plays a pivotal role in the development of innovative therapeutics. Its azido component readily conjugates with diverse bioactive molecules, aiding in the screening and identification of potential drug candidates. This compound serves as a significant tool in constructing compound libraries for high-throughput drug screening initiatives, leading to a burst of possibilities in discovering novel drug solutions.
Protein Labeling: Researchers harness the potential of 3-Azido-N-Boc-D-Alanine for precise site-specific labeling of proteins and biomolecules. The selective attachment of the azido group to fluorescent dyes or affinity tags through click chemistry empowers the analysis of protein dynamics, interactions, and localization within cellular environments. This sophisticated approach enriches our comprehension of protein functionality and navigates the intricate landscape of cellular mechanisms with an exquisite blend of complexity and variation.
Chemical Biology: In the domain of chemical biology, 3-Azido-N-Boc-D-Alanine serves as a crucial component for probing and manipulating biological pathways. It acts as a foundational element for generating bioorthogonal probes and sensors, offering real-time tracking capabilities for monitoring cellular processes. This innovative methodology is indispensable for unraveling the intricate web of biological interactions and designing targeted molecular interventions with a rich tapestry of complexity and intricacy.
3-Azido-N-Boc-D-Alanine
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3-Azido-N-Boc-D-Alanine
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