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Mal-PEG8-NHS is a PEG-containing maleimide conjugation reagent designed for thiol-reactive coupling. The maleimide group provides a selective handle for sulfhydryl-containing molecules, while the opposite terminus and spacer determine how the reagent can be connected to a payload, linker intermediate, or additional functional module. The molecule incorporates peg8 spacer and provides opposite-end functionality not fully defined from the name; maleimide itself is typically reserved for antibody thiol conjugation on the opposite side. It can be used in stepwise conjugation workflows that combine thiol-maleimide coupling with an orthogonal second reaction, with reaction order selected to suit the stability and accessibility of each functional group.
Structure of 756525-93-6
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