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DM3-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). .
DM3-SMe, also referred to as demethylated maytansine derivative, stands out as a potent cytotoxic compound with diverse applications in biomedical research and therapeutic realms. Here are four key applications of DM3-SMe intricately:
Cancer Research: A pivotal player in the realm of cancer research, DM3-SMe finds extensive utility in the development of antibody-drug conjugates (ADCs) targeted at eradicating cancer cells. It operates by conjugating to an antibody specific to a tumor cell antigen, facilitating the direct delivery of the potent cytotoxic agent to the cancerous cells. This targeted strategy not only minimizes harm to healthy cells but also amplifies therapeutic effectiveness.
Drug Development: Serving as a lead compound in the synthesis of novel chemotherapeutic agents, DM3-SMe empowers researchers in creating derivatives with enhanced potency, selectivity, and reduced side effects. This compound propels the exploration of innovative treatments for diverse cancer types, heralding a new era of drug development and personalized medicine.
Cell Biology Studies: Within cell biology, DM3-SMe assumes a pivotal role in elucidating the impact of microtubule inhibitors on cell division and proliferation dynamics. By disrupting microtubule dynamics, it illuminates the intricacies of cell division mechanisms, unveiling potential therapeutic targets for diseases characterized by unregulated cell proliferation. This profound knowledge serves as a cornerstone for designing cutting-edge cancer therapeutics.
Mechanism of Action Studies: Eminently valuable for decoding the molecular mechanisms underpinning its cytotoxic effects, DM3-SMe is instrumental in unraveling its interactions with cellular components like tubulin and its role in inducing cell death. By comprehending these intricate mechanisms, researchers pave the way for crafting more potent anti-cancer strategies and identifying novel drug targets to combat malignant diseases efficaciously.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
