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DM4 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00017 | -- | $-- | Inquiry |
DM4-SMCC is a potent cytotoxic agent used in the development of antibody-drug conjugates (ADCs). Here are some key applications of DM4-SMCC:
Cancer Therapy: DM4-SMCC is utilized in the creation of ADCs that specifically target cancer cells, delivering the cytotoxic drug directly to the tumor site. By linking DM4-SMCC to monoclonal antibodies that recognize cancer-specific markers, targeted killing of cancer cells is achieved while sparing healthy cells, thus reducing side effects. This targeted approach increases the therapeutic index and efficacy of cancer treatments.
Target Validation: In preclinical studies, DM4-SMCC can be used to validate potential therapeutic targets. By conjugating DM4-SMCC to antibodies against new tumor markers, researchers can evaluate the effectiveness of targeting those markers in cell and animal models. This helps in identifying promising targets for the development of new cancer therapies.
Drug Resistance Research: DM4-SMCC is instrumental in studying mechanisms of drug resistance in cancer cells. By using ADCs containing DM4-SMCC, researchers can investigate how cancer cells develop resistance to targeted cytotoxic agents. This knowledge contributes to the design of next-generation ADCs with improved resistance profiles.
Pharmacokinetics and Toxicology Studies: DM4-SMCC is employed in pharmacokinetic and toxicology studies to assess the distribution, metabolism, and potential toxic effects of ADCs. By studying the behavior of DM4-SMCC conjugates in biological systems, researchers can optimize dosing regimens and enhance the safety profile of ADC-based therapies. This is essential for the successful translation of ADCs from bench to bedside.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
