DM4 with a reactive linker sulfo-SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site.
Structure of 1626359-59-8
* For research and manufacturing use only. We do not sell to patients.
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Capabilities & Facilities
Sulfo-SPDB-DM4 is a high-performance ADC Cytotoxin with Linker designed for targeted cancer therapy and advanced antibody-drug conjugate (ADC) development. This potent ADC Cytotoxin combines the cytotoxic potency of DM4 with a stable sulfonated SPDB linker, enabling efficient delivery of the payload to tumor cells while minimizing systemic toxicity. The ADC Linker plays a critical role in maintaining stability in circulation and ensuring controlled release of the ADC payload upon internalization by target cells.
The mechanism of sulfo-SPDB-DM4 involves selective binding of the antibody component to tumor-associated antigens, followed by internalization and proteolytic cleavage of the ADC linker, releasing the DM4 payload intracellularly. This process facilitates microtubule disruption, leading to apoptosis of malignant cells. As an optimized ADC Cytotoxin, sulfo-SPDB-DM4 is highly relevant for researchers and developers working on targeted therapeutics, bioconjugation techniques, and ADC pipeline expansion. Its design ensures both efficacy and safety, critical parameters for preclinical and clinical ADC applications.
Sulfo-SPDB-DM4 also supports versatile ADC bioconjugation strategies, allowing efficient coupling with various monoclonal antibodies. The water-soluble sulfonated linker enhances conjugation efficiency and solubility, addressing common challenges in ADC formulation and development. This feature makes it a preferred choice for pharmaceutical scientists exploring novel ADC payload-linker combinations, tumor-targeting modalities, and next-generation oncology therapeutics. Incorporating this ADC Cytotoxin with Linker into research workflows can accelerate development timelines and improve the therapeutic index of antibody-based drugs.
Applications of sulfo-SPDB-DM4 include preclinical testing of antibody-drug conjugates, ADC optimization studies, and investigation of targeted cytotoxic delivery mechanisms. Its reliable performance in ADC payload release and linker stability evaluation makes it an essential tool for cancer research, bioconjugation chemistry, and translational oncology programs.
Catalog | Product Name | CAS | Inquiry |
---|---|---|---|
BADC-00017 | DM4-SMCC | 1228105-52-9 | |
BADC-01467 | Lys-Nε-SPDB-DM4 | 1280215-91-9 | |
BADC-00600 | Sulfo-PDBA-DM4 | 1461704-01-7 | |
BADC-00012 | DM4-SPDB | 1626359-62-3 | |
BADC-00011 | DM4-SPDP | 2245698-48-8 | |
BADC-00021 | DM4-SMe | 796073-68-2 | |
BADC-00347 | DM4 | 796073-69-3 | |
BADC-00087 | Maytansinoid DM4 | 799840-96-3 | |
BADC-01365 | S-Me-DM4 | 890654-03-2 | |
BADC-00704 | DBA-DM4 | 905449-84-5 |
What is sulfo-SPDB-DM4?
sulfo-SPDB-DM4 is an antibody-drug conjugate (ADC) linker-payload. It is comprised of a cleavable linker (sulfo-SPDB) and a potent tubulin-targeting payload (DM4). This combination is used for the site-specific conjugation of antibodies to create ADCs for targeted drug delivery in cancer therapy.
12/12/2018
We would like to know how sulfo-SPDB-DM4 is used in ADC development.
sulfo-SPDB-DM4 is used as a crucial component in the synthesis of ADCs. The sulfo-SPDB linker, a non-cleavable maleimide-based linker, ensures stable attachment to the antibody, while the DM4 payload provides the cytotoxic activity. Its use allows for the creation of ADCs with high stability and a consistent drug-to-antibody ratio (DAR).
9/3/2019
Good morning! Could you please explain the key advantages of using sulfo-SPDB-DM4?
The primary advantage of sulfo-SPDB-DM4 lies in its stability and targeted delivery. The sulfo-SPDB linker is designed to be highly stable in circulation, minimizing premature payload release. This feature reduces systemic toxicity. The DM4 payload, a highly potent tubulin inhibitor, ensures effective cell killing upon reaching the target site.
28/11/2020
Could you please explain what the mechanism of action of the DM4 payload is?
The DM4 payload is a maytansinoid, a class of potent antimitotic agents. Its mechanism of action involves the inhibition of tubulin polymerization, which disrupts the microtubule network within cancer cells. This disruption leads to cell cycle arrest at the G2/M phase and subsequent apoptosis, or programmed cell death.
18/9/2020
Good afternoon! Could you explain why the sulfo-SPDB linker is important?
The sulfo-SPDB linker is a key part of the sulfo-SPDB-DM4 construct. It provides a covalent and stable connection between the antibody and the DM4 payload, a critical feature for maintaining the integrity of the ADC in the bloodstream. This linker also features a sulfo group, enhancing its water solubility and facilitating its use in aqueous conjugation reactions.
25/9/2017
— Dr. Laura Bennett, Senior Scientist (USA)
The high purity of sulfo-SPDB-DM4 enabled accurate ADC conjugation and reliable assay results in our lab.
28/11/2020
— Dr. Michael Carter, ADC Chemist (UK)
We appreciated the rapid shipment of sulfo-SPDB-DM4, which helped us meet a tight project deadline.
25/9/2017
— Dr. Stefan Müller, Medicinal Chemist (Germany)
Technical advice provided by BOC Sciences was invaluable for optimizing sulfo-SPDB-DM4 handling.
18/9/2020
— Dr. Emily White, Biochemist (Canada)
Consistency across batches of sulfo-SPDB-DM4 reduced variability and improved experiment reproducibility.
12/12/2018
— Dr. Robert Thompson, Lead Scientist (USA)
The detailed QC documentation of sulfo-SPDB-DM4 allowed us to validate our conjugation protocol efficiently.
— Dr. Camille Laurent, Pharmacology Scientist (France)
Sulfo-SPDB-DM4 quality, combined with responsive customer support, significantly accelerated our ADC research.
9/3/2019
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