AcLysValCit-PABC-DMAE-SW-163D - CAS 2411007-69-5

AcLysValCit-PABC-DMAE-SW-163D - CAS 2411007-69-5 Catalog number: BADC-00869

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AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker.

Category
ADCs Cytotoxin
Product Name
AcLysValCit-PABC-DMAE-SW-163D
CAS
2411007-69-5
Catalog Number
BADC-00869
Molecular Formula
C85H113N19O22S2
Molecular Weight
1817.05

Ordering Information

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BADC-00869 -- $--
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Description
AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker.
Canonical SMILES
CC1CC12C(=O)OCC(C(=O)NC(C(=O)N(C3C(SCC(C(=O)N2C)N(C(=O)C(NC(=O)C(COC(=O)C4(CC4C)N(C3=O)C)NC(=O)C5=NC6=CC=CC=C6C=C5O)C)C)SC)C)C)NC(=O)C7=NC8=CC=CC=C8C=C7OC(=O)N(C)CCN(C)C(=O)OCC9=CC=C(C=C9)NC(=O)C(CCCNC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C
InChI
InChI=1S/C85H113N19O22S2/c1-44(2)63(98-68(108)56(91-49(7)105)26-19-20-32-86)71(111)95-57(27-21-33-88-81(87)120)67(107)92-53-30-28-50(29-31-53)40-125-82(121)99(8)34-35-100(9)83(122)126-62-37-52-23-16-18-25-55(52)94-65(62)73(113)97-59-42-123-79(118)84(38-45(84)3)103(12)76(116)60-43-128-78(127-14)66(102(11)75(115)48(6)90-70(59)110)77(117)104(13)85(39-46(85)4)80(119)124-41-58(69(109)89-47(5)74(114)101(60)10)96-72(112)64-61(106)36-51-22-15-17-24-54(51)93-64/h15-18,22-25,28-31,36-37,44-48,56-60,63,66,78,106H,19-21,26-27,32-35,38-43,86H2,1-14H3,(H,89,109)(H,90,110)(H,91,105)(H,92,107)(H,95,111)(H,96,112)(H,97,113)(H,98,108)(H3,87,88,120)/t45-,46-,47-,48-,56+,57-,58+,59+,60-,63-,66+,78-,84-,85-/m0/s1
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
-20°C (International: -20°C)
Storage
Store at -5°C,keep in dry and avoid sunlight.
Form
Solid

AcLysValCit-PABC-DMAE-SW-163D is a complex compound primarily used in targeted drug delivery systems. Here are some key applications of AcLysValCit-PABC-DMAE-SW-163D:

Cancer Therapy: AcLysValCit-PABC-DMAE-SW-163D can be conjugated with cytotoxic drugs to form antibody-drug conjugates (ADCs) that specifically target cancer cells. This targeted approach minimizes damage to healthy cells and reduces side effects associated with traditional chemotherapy. The compound acts as a linker, enabling the precise release of the therapeutic agent within the tumor microenvironment.

Immunotherapy: In immunotherapy, AcLysValCit-PABC-DMAE-SW-163D can be used to enhance the delivery and effectiveness of immune-modulating drugs. By attaching immunotherapeutic agents to this linker, the drug can be more accurately directed to immune cells or cancer cells. This helps in boosting the body's immune response against tumors and improving treatment outcomes.

Bioconjugation Research: AcLysValCit-PABC-DMAE-SW-163D serves as a versatile linker in bioconjugation studies, facilitating the development of new drug delivery systems. Researchers can use it to link a wide variety of therapeutic molecules to targeting moieties, such as antibodies or peptides. This broadens the range of diseases that can be targeted with precision medicine approaches.

Diagnostic Imaging: The compound can also be applied in diagnostic imaging, where it aids in the targeted delivery of imaging agents. By conjugating imaging molecules with AcLysValCit-PABC-DMAE-SW-163D, clinicians can achieve more precise localization of disease sites using advanced imaging techniques. This improves the accuracy of diagnostics and enables better monitoring of disease progression and treatment efficacy.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: AcLysValCit-PABC-DMAE-SW-163D
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