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SCO-PEG3-Maleimide

  CAS No.: 2141976-35-2   Cat No.: BADC-01796 4.5  

SCO-PEG3-Maleimide is a strain-promoted cyclooctyne ADC linker with PEG3 spacer and maleimide group, facilitating rapid and selective thiol-reactive conjugation in antibody-drug conjugates for stable payload attachment. Keywords: ADC linker, SCO linker, PEG spacer, maleimide linker, thiol conjugation.

SCO-PEG3-Maleimide

Structure of 2141976-35-2

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ADC Linker
Molecular Formula
C24H35N3O8
Molecular Weight
493.55

* For research and manufacturing use only. We do not sell to patients.

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IUPAC Name
cyclooct-2-yn-1-yl N-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Canonical SMILES
C1CCC#CC(CC1)OC(=O)NCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O
InChI
InChI=1S/C24H35N3O8/c28-21(10-13-27-22(29)8-9-23(27)30)25-11-14-32-16-18-34-19-17-33-15-12-26-24(31)35-20-6-4-2-1-3-5-7-20/h8-9,20H,1-4,6,10-19H2,(H,25,28)(H,26,31)
InChIKey
OMJLWTJLSDMFKY-UHFFFAOYSA-N

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Historical Records: NH2-PEG1-Val-Cit-PAB-OH | EGGGG-PEG8-amide-bis(deoxyglucitol) | Fmoc-PEG2-Val-Cit-PAB-OH | Sco-peg2-NH2 | L-Ornithinamide, N-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- | L-Val-D-Cit-PAB | Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 | Py-MAA-Val-Cit-PAB-MMAE | diMal-O-CH2COOH | MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D | SCO-PEG3-Maleimide
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