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CAS No.:
Cat No.: BADC-01910
4.5 
(S)-TCO-PEG7-NH2 is a trans-cyclooctene PEG linker with amine functional group facilitating rapid bioorthogonal conjugation and stable payload attachment in antibody-drug conjugates for targeted delivery. Keywords: ADC linker, trans-cyclooctene linker, PEG spacer, amine group, bioconjugation.
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(S)-TCO-PEG7-NH2, a versatile compound prevalent in biomedical research and drug development, boasts diverse applications due to its unique properties. Here are four key applications of (S)-TCO-PEG7-NH2, presented with a high degree of perplexity and burstiness:
Bioorthogonal Chemistry: Positioned at the forefront of bioorthogonal chemistry, (S)-TCO-PEG7-NH2 assumes a pivotal role in facilitating precise labeling and tracking of biomolecules within living systems. With its tetrazine-reactive TCO group, this compound enables efficient conjugation without disrupting native biological processes, unveiling intricate biochemical dynamics and cellular interactions that illuminate the complexities of biological phenomena.
Drug Delivery Systems: A catalyst for innovation in drug delivery systems, (S)-TCO-PEG7-NH2 enhances the properties of nanoparticles and liposomes, optimizing their pharmacokinetics. The hydrophilic and flexible PEG7 spacer enhances circulation time and reduces immunogenicity, ensuring targeted drug delivery and maximizing therapeutic efficacy for improved patient outcomes.
Bioconjugation: Central to bioconjugation breakthroughs, (S)-TCO-PEG7-NH2 serves as a crucial linker for attaching diverse biomolecules, such as antibodies, proteins, or peptides, to therapeutic agents or imaging probes. The rapid and specific reaction of the TCO group with tetrazine-functionalized molecules enables precise bioconjugation, driving the development of tailored therapies and diagnostic tools for enhanced medical interventions.
Surface Functionalization: Embarking on surface functionalization endeavors, (S)-TCO-PEG7-NH2 transforms biomaterial surfaces to enhance biocompatibility, reducing non-specific binding. The PEGylation conferred by the PEG7 chain minimizes protein adsorption and cell adhesion, making it ideal for biomedical implants and devices. This optimization elevates the performance and durability of medical implants, minimizing complications and enhancing patient outcomes to advanced levels.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01894 | (S)-TCO-PEG2-Maleimide | ||
| BADC-01903 | (S)-TCO-PEG2-NH2 | ||
| BADC-01911 | (S)-TCO-PEG3-NH2 |
(S)-TCO-PEG7-NH2
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(S)-TCO-PEG7-NH2
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