Name: Mal-C2-Gly3-EDA
Brand: BOC Sciences
Rating: 5 (1 reviews)

Solubility

10 mm in DMSO

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Mal-C2-Gly3-EDA is a versatile compound widely used in the field of bioconjugation, particularly for the modification of biomolecules such as proteins, peptides, and nucleic acids. The structure of Mal-C2-Gly3-EDA consists of a malonic acid group, a glycine linker (Gly3), and an ethylenediamine (EDA) moiety, which enables the conjugation of the compound to various biomolecules via amine-reactive chemistry. The malonic acid group provides a convenient site for chemical modification, while the glycine spacer enhances flexibility and minimizes steric hindrance during conjugation. This makes Mal-C2-Gly3-EDA an ideal tool for developing stable conjugates for therapeutic and diagnostic applications.

A key application of Mal-C2-Gly3-EDA is in the development of targeted drug delivery systems. The compound can be conjugated to drugs, antibodies, or other targeting moieties, forming a prodrug or drug conjugate that can specifically bind to diseased cells, such as cancer cells, through a biomolecular target. The ethylenediamine linker in Mal-C2-Gly3-EDA allows for efficient coupling to amine-functionalized molecules, enhancing the precision of drug delivery. By conjugating cytotoxic agents or therapeutic proteins to the Mal-C2-Gly3-EDA linker, drugs can be directed to tumor sites, thereby reducing systemic toxicity and improving therapeutic efficacy. This application is particularly useful in the creation of antibody-drug conjugates (ADCs) and other targeted therapies.

Mal-C2-Gly3-EDA is also used in the synthesis of peptide-based biomaterials and scaffolds. The flexibility provided by the glycine spacer, combined with the amine-reactive ethylenediamine group, allows for the precise assembly of complex peptide constructs. These constructs can be used for a variety of purposes, including tissue engineering, drug delivery, and the creation of bioactive surfaces. In particular, Mal-C2-Gly3-EDA is useful for creating functional peptide coatings on nanoparticles or other delivery systems, improving their stability, biocompatibility, and targeting capabilities. This application holds promise for advancing the development of peptide-based vaccines, diagnostic devices, and personalized therapeutics.