Name: DGN549
Brand: BOC Sciences
Rating: 5 (1 reviews)

Shipping

Room temperature, or blue ice upon request.

Storage

-20°C

In Vitro

Using TAK-164, an anti-GCC ADC undergoing clinical evaluation, the research show that the lipophilic DNA-alkylating payload, DGN549, penetrates beyond the cell targeted layer in GCC-positive tumor spheroids and primary human tumor xenograft models. The penetration distance is similar to model predictions, where the lipophilicity results in moderate tissue penetration, thereby balancing improved tissue penetration with sufficient cellular uptake to avoid significant washout. These results aid in mechanistic understanding of the interplay between antigen heterogeneity, bystander effects, and heterogeneous delivery of ADCs in the tumor microenvironment to design clinically effective therapeutics.

DGN549 is a novel bioscience product with significant potential in various areas of scientific research and application. Here are some key applications of DGN549:

Cancer Research: DGN549 is employed to inhibit specific signaling pathways implicated in tumor progression and metastasis. By targeting these pathways, researchers can study the mechanisms of cancer cell proliferation and survival. This makes DGN549 an invaluable tool for developing targeted cancer therapies and understanding tumor biology.

Neuroscience: In neuroscience, DGN549 is utilized to probe the role of certain proteins in neurodegenerative diseases like Alzheimer’s and Parkinson’s. By inhibiting or modulating these proteins, scientists can explore their effects on neuronal function and neuroinflammation. This aids in the development of potential treatments and improves our understanding of neurological disorders.

Inflammatory Disease Studies: DGN549 is used to investigate the molecular mechanisms underlying various inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. By modulating inflammatory responses, the compound helps researchers identify therapeutic targets and understand disease pathogenesis. This paves the way for the creation of novel anti-inflammatory drugs.

Biochemical Pathway Analysis: DGN549 plays a crucial role in studying specific biochemical pathways and enzyme activities. Researchers use it to assess the impact on metabolic fluxes and the overall behavior of biochemical networks. This information is critical for optimizing biotechnological processes and designing effective metabolic engineering strategies for various industrial applications.