DGN549

DGN549 Catalog number: BADC-00747

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DGN549 is a drug-linker conjugate for ADC.

Category
ADCs Cytotoxin with Linkers
Product Name
DGN549
Catalog Number
BADC-00747
Molecular Formula
C60H61N9O12
Molecular Weight
1100.20
DGN549

Ordering Information

Catalog Number Size Price Quantity
BADC-00747 -- $--
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Description
DGN549 is a drug-linker conjugate for ADC.
In Vitro
Using TAK-164, an anti-GCC ADC undergoing clinical evaluation, the research show that the lipophilic DNA-alkylating payload, DGN549, penetrates beyond the cell targeted layer in GCC-positive tumor spheroids and primary human tumor xenograft models. The penetration distance is similar to model predictions, where the lipophilicity results in moderate tissue penetration, thereby balancing improved tissue penetration with sufficient cellular uptake to avoid significant washout. These results aid in mechanistic understanding of the interplay between antigen heterogeneity, bystander effects, and heterogeneous delivery of ADCs in the tumor microenvironment to design clinically effective therapeutics.
Shipping
Room temperature, or blue ice upon request.
Storage
-20°C
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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