Name: Acid-PEG2-SS-PEG2-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

4,7,14,17-Tetraoxa-10,11-dithiaicosanedioic acid

IUPAC Name

Canonical SMILES

C(COCCOCCSSCCOCCOCCC(=O)O)C(=O)O

InChI

InChI=1S/C14H26O8S2/c15-13(16)1-3-19-5-7-21-9-11-23-24-12-10-22-8-6-20-4-2-14(17)18/h1-12H2,(H,15,16)(H,17,18)

InChIKey

TZKZHEPGHNBGKD-UHFFFAOYSA-N

Density

1.3±0.1 g/cm3

Solubility

10 mm in DMSO

Flash Point

300.9±30.1 °C

Index Of Refraction

1.528

Vapor Pressure

0.0±3.4 mmHg at 25°C

Appearance

Solid

Shelf Life

-20°C 3 years powder; -80°C 2 years in solvent

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Boiling Point

573.9±50.0 °C at 760 mmHg

Form

Solid

Biological Activity

Acid-PEG2-SS-PEG2-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1] .

Acid-PEG2-SS-PEG2-acid, a versatile bifunctional reagent, finds diverse applications in bioconjugation and drug delivery. Here are four key applications presented with high perplexity and burstiness://

Antibody-Drug Conjugates: Utilizing Acid-PEG2-SS-PEG2-acid, researchers forge a crucial link between therapeutic agents and antibodies to create potent antibody-drug conjugates (ADCs). These specialized conjugates target cancer cells with pinpoint accuracy, ushering in a new era of precision cytotoxic drug delivery. This targeted delivery strategy minimizes harm to healthy tissues while maximizing the efficacy of anti-cancer treatments.

Protein-Protein Crosslinking: Through the artful crosslinking of proteins, Acid-PEG2-SS-PEG2-acid facilitates in-depth exploration of protein interactions and intricate complex formations. By establishing robust disulfide bonds between proteins, scientists can dissect protein assemblies using cutting-edge tools like mass spectrometry and X-ray crystallography. This wealth of information is indispensable for unraveling the mysteries of protein functions and interplays within cellular dynamics.

Controlled Drug Release: Delving into the realm of drug delivery systems, Acid-PEG2-SS-PEG2-acid plays a pivotal role in engineering platforms with finely tuned release mechanisms. The sensitive disulfide linkage within this compound responds to the reductive milieu inside cells, orchestrating the precise release of therapeutic payloads at designated sites. This targeted drug release paradigm heightens treatment efficacy, narrowing the therapeutic window and diminishing adverse effects associated with systemic drug circulation.

Surface Modification: In the realm of material science, Acid-PEG2-SS-PEG2-acid emerges as a transformative tool for surface engineering of nanoparticles and diverse materials. By grafting functional moieties onto surfaces, researchers sculpt material properties to cater to biomedical applications such as precision drug delivery and biosensing. This tailored surface modification strategy elevates the biocompatibility and performance benchmarks of nanomaterials across a spectrum of cutting-edge applications.