Name: Acid-PEG3-SS-PEG3-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Synonyms

4,7,10,17,20,23-hexaoxa-13,14-dithiahexacosanedioic acid

IUPAC Name

Canonical SMILES

C(COCCOCCOCCSSCCOCCOCCOCCC(=O)O)C(=O)O

InChI

InChI=1S/C18H34O10S2/c19-17(20)1-3-23-5-7-25-9-11-27-13-15-29-30-16-14-28-12-10-26-8-6-24-4-2-18(21)22/h1-16H2,(H,19,20)(H,21,22)

InChIKey

DLBWMEFQLZTRTD-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Appearance

Solid

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Form

Solid

Acid-PEG3-SS-PEG3-acid is a bifunctional polyethylene glycol (PEG) linker used in various bioconjugation and drug delivery applications. Here are some key applications of Acid-PEG3-SS-PEG3-acid:

Antibody-Drug Conjugates (ADCs): Acid-PEG3-SS-PEG3-acid is used in the development of ADCs by linking cytotoxic drugs to antibodies. The disulfide bond in the linker is cleavable in the reductive environment of cancer cells, ensuring targeted release of the drug. This targeted delivery system minimizes damage to healthy tissues and enhances the efficacy of cancer treatment.

Protein Modification: This bifunctional linker is used to modify proteins and peptides to improve their pharmacokinetic properties, such as solubility and stability. By attaching Acid-PEG3-SS-PEG3-acid to therapeutic proteins, researchers can reduce immunogenicity and prolong circulation time in the bloodstream. This modification aids in the development of more effective biopharmaceuticals.

Nanoparticle Functionalization: Acid-PEG3-SS-PEG3-acid can be employed to functionalize nanoparticles for improved drug delivery and diagnostic imaging. The PEG segments enhance the biocompatibility and circulation time of nanoparticles, while the disulfide linker allows for controlled release of the therapeutic payload. This approach is used to create targeted nanocarriers that can deliver drugs to specific tissues or cells.

Surface Coating: In biosensor development, Acid-PEG3-SS-PEG3-acid is used to coat sensor surfaces, providing a non-fouling layer that prevents non-specific binding. The PEG linker enhances the biocompatibility and sensitivity of the sensors, improving their performance in complex biological samples. This application is crucial for the development of reliable diagnostic and analytical devices.