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CAS No.: 2144777-72-8
Cat No.: BADC-01074
Purity: >98.0%
4.5 
Azido-C2-SS-PEG2-C2-acid is a disulfide-containing ADC linker with azide and PEG spacers, enabling stable, cleavable antibody conjugation and efficient payload release via bioorthogonal click chemistry.
Structure of 2144777-72-8
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Azido-C2-SS-PEG2-C2-acid is a versatile bifunctional reagent used in various bioconjugation and molecular biology applications. Here are some key uses of Azido-C2-SS-PEG2-C2-acid:
Site-Specific Protein Labeling: Azido-C2-SS-PEG2-C2-acid can be employed for site-specific labeling of proteins with fluorescent dyes, biotin, or other tags. This reagent uses a cleavable disulfide bond to covalently attach the azide group to proteins, allowing for controlled and reversible modifications. This technique is crucial for studying protein localization, interactions, and dynamics.
Drug Delivery Systems: This bifunctional compound can be used to engineer drug delivery systems by conjugating therapeutic agents to carrier molecules. The presence of a PEG (polyethylene glycol) linker provides improved solubility and biocompatibility, enhancing drug efficacy and reducing toxicity. The cleavable disulfide bond allows for controlled release of the drug at the target site, improving precision in treatment.
Biomaterials Engineering: Azido-C2-SS-PEG2-C2-acid can be instrumental in the design and functionalization of biomaterials for tissue engineering and regenerative medicine. By modifying the surface of biomaterials with this reagent, researchers can improve cell adhesion, growth, and differentiation. This provides a means to create scaffolds and other biomaterials that better mimic the natural extracellular matrix.
Click Chemistry Reactions: The azide moiety in Azido-C2-SS-PEG2-C2-acid makes it ideal for use in click chemistry reactions, which are widely used for bioconjugation. These reactions are highly specific and efficient, allowing for the attachment of various functional groups to biomolecules. This application is valuable in creating complex molecular assemblies, biosensors, and diagnostic tools.
Azido-C2-SS-PEG2-C2-acid
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Azido-C2-SS-PEG2-C2-acid
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