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DGN549-C consists a cleavable ADC linker valine-alanine (va) and PBD dimer. DGN549 is a novel DNA-alkylating cytotoxic payload and can be used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00859 | -- | $-- |
DGN549-C is a versatile compound with multiple applications in the bioscience sector. Here are some key applications of DGN549-C:
Cancer Research: DGN549-C is used in cancer research for its potential to inhibit tumor growth and induce apoptosis in cancerous cells. Researchers utilize DGN549-C to study its mechanism of action and its effects on various cancer cell lines. This aids in discovering new therapeutic strategies and developing anti-cancer drugs.
Drug Discovery: DGN549-C serves as a lead compound in drug discovery programs aimed at developing treatments for various diseases. By assessing the bioactivity and safety profile of DGN549-C, researchers can identify promising drug candidates. This facilitates the development of new medications with enhanced efficacy and reduced side effects.
Pharmacokinetics Studies: DGN549-C is employed in pharmacokinetic studies to evaluate its absorption, distribution, metabolism, and excretion (ADME) properties. Understanding the pharmacokinetics of DGN549-C helps in optimizing its formulation and dosing regimens for therapeutic use. This information is essential for ensuring the safety and effectiveness of the compound in clinical settings.
Biological Pathways Research: DGN549-C is used to probe and manipulate biological pathways related to disease mechanisms and cellular functions. By treating cells or model organisms with DGN549-C, researchers can investigate its impact on specific signaling pathways and gene expression profiles. This contributes to a deeper understanding of disease biology and identification of novel therapeutic targets.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
