Boc-Val-Cit-PABA - CAS 870487-09-5

Boc-Val-Cit-PABA - CAS 870487-09-5 Catalog number: BADC-00697

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Boc-Val-Cit-PABA is a linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.

General Information

Category
ADCs Linker
Product Name
Boc-Val-Cit-PABA
CAS
870487-09-5
Catalog Number
BADC-00697
Molecular Formula
C23H37N5O6
Molecular Weight
479.57

Chemical Structure

  • Boc-Val-Cit-PABA
Synonyms
tert-butyl N-[1-[[5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OC(C)(C)C
InChI Key
VYCVAPFXSOAOCL-UHFFFAOYSA-N
InChI
InChI=1S/C23H37N5O6/c1-14(2)18(28-22(33)34-23(3,4)5)20(31)27-17(7-6-12-25-21(24)32)19(30)26-16-10-8-15(13-29)9-11-16/h8-11,14,17-18,29H,6-7,12-13H2,1-5H3,(H,26,30)(H,27,31)(H,28,33)(H3,24,25,32)

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