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Boc-Val-Cit-PABA - CAS 870487-09-5 Catalog number: BADC-00697
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Boc-Val-Cit-PABA is a linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.
General Information
Category
ADCs Linker
Product Name
Boc-Val-Cit-PABA
CAS
870487-09-5
Catalog Number
BADC-00697
Molecular Formula
C23H37N5O6
Molecular Weight
479.57
Chemical Structure
Synonyms
tert-butyl N-[1-[[5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OC(C)(C)C
InChI Key
VYCVAPFXSOAOCL-UHFFFAOYSA-N
InChI
InChI=1S/C23H37N5O6/c1-14(2)18(28-22(33)34-23(3,4)5)20(31)27-17(7-6-12-25-21(24)32)19(30)26-16-10-8-15(13-29)9-11-16/h8-11,14,17-18,29H,6-7,12-13H2,1-5H3,(H,26,30)(H,27,31)(H,28,33)(H3,24,25,32)
