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CAS No.: 1308299-09-3
Cat No.: BADC-00919
Purity: ≥98%
4.5 
Propargyl-PEG4-Br is an ADC linker featuring a PEG4 spacer and bromide reactive group. It supports efficient click chemistry and nucleophilic substitution reactions, improving targeted payload attachment and stability in antibody-drug conjugates.
Structure of 1308299-09-3
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Propargyl-PEG4-Br is a versatile ADC linker intermediate widely employed in the design and construction of antibody-drug conjugates (ADCs) and targeted bioconjugation studies. Featuring a hydrophilic PEG4 spacer, a terminal propargyl group, and a bromide functionality, it enables efficient and site-specific conjugation with ADC cytotoxins and monoclonal antibodies. The PEG4 chain enhances solubility and reduces steric hindrance, while the bromide serves as a reactive site for nucleophilic substitution or click chemistry, supporting flexible ADC linker design. In ADC linker applications, Propargyl-PEG4-Br maintains antibody integrity and facilitates controlled intracellular payload delivery.
In payload conjugation applications, Propargyl-PEG4-Br is compatible with a broad range of ADC cytotoxins, including microtubule inhibitors, DNA-targeting agents, and other potent therapeutic payloads. Its PEG4 spacer improves aqueous solubility and flexibility, allowing homogeneous and stable ADC construction. The terminal propargyl group enables modular click chemistry, while the bromide functionality provides additional conjugation versatility for secondary payload attachment. Researchers can leverage this linker intermediate to optimize linker length, improve payload release, and construct high-performance ADCs suitable for both preclinical research and scalable industrial production.
From an application perspective, Propargyl-PEG4-Br is extensively used in oncology-focused ADC research, targeted drug delivery systems, and protein bioconjugation studies. Its hydrophilic PEG spacer enhances circulation time and reduces aggregation of ADC payloads, while the combination of bromide and propargyl groups ensures efficient, site-specific, and flexible conjugation strategies. By integrating Propargyl-PEG4-Br into ADC linker design, developers can construct stable, flexible, and highly soluble linker-payload conjugates, supporting tumor-specific delivery and optimized pharmacokinetics in modern ADC development.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01045 | Propargyl-PEG9-bromide | 2055042-83-4 | |
| BADC-01046 | Propargyl-PEG8-bromide | 2055046-25-6 |
What is Propargyl-PEG4-Br and its application in ADCs?
Propargyl-PEG4-Br is a short PEG linker with a bromide terminal for nucleophilic reactions and a propargyl group for click conjugation. It provides a balance of solubility and functional versatility in ADC construction.
22/2/2019
Dear team, how does Propargyl-PEG4-Br facilitate payload attachment?
The bromide group reacts with nucleophiles such as thiols, while the propargyl moiety supports click chemistry, enabling site-selective conjugation of cytotoxins to antibodies with minimal off-target reactions.
22/10/2022
Dear team, what are the key handling precautions for Propargyl-PEG4-Br?
Propargyl-PEG4-Br should be handled under dry, inert conditions to prevent hydrolysis or unwanted side reactions. Store at low temperature and away from light to maintain chemical integrity for ADC synthesis.
10/10/2022
Good morning! Which antibodies or payloads are compatible with Propargyl-PEG4-Br?
Propargyl-PEG4-Br can conjugate to antibodies with exposed thiol or amine groups and is compatible with azide-functionalized cytotoxins. Its PEG4 spacer improves solubility and reduces steric hindrance during conjugation.
27/4/2020
Dear BOC Sciences, which tests do you recommend to confirm the functional integrity of Propargyl-PEG4-Br?
Functional integrity of Propargyl-PEG4-Br can be confirmed using NMR spectroscopy and mass spectrometry, which verify the presence of both the propargyl group and bromide functionality. Routine analytical checks ensure its suitability for click chemistry and ADC conjugation reactions.
4/9/2020
— Dr. Matthew Green, Biochemist (UK)
Propargyl-PEG4-Br offered excellent reactivity in our alkyne-based conjugation reactions.
10/10/2022
— Ms. Anna Weber, Senior Scientist (Germany)
Lot consistency ensured reproducible incorporation in multi-step synthesis.
4/9/2020
— Dr. Daniel Clark, ADC Development Scientist (USA)
High yields and minimal side products allowed smooth linker synthesis.
27/4/2020
— Dr. Sophie Laurent, Medicinal Chemist (France)
The reagent integrated well into our existing PEGylation workflows.
22/2/2019
— Dr. Lucas Meyer, Chemist (Germany)
Propargyl-PEG4-Br enabled development of extended PEG linkers for improved solubility.
— Dr. Clara Müller, Organic Chemist (Germany)
Propargyl-PEG4-Br allowed smooth click chemistry modifications in our lab. Excellent batch quality and documentation facilitated quick implementation.
22/10/2022
Propargyl-PEG4-Br
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Propargyl-PEG4-Br
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