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Mal(Br2)-Aca

  CAS No.: 1443214-97-8   Cat No.: BADC-01710 4.5  

Mal(Br2)-Aca is a bifunctional dibromomaleimide (DBM) linker. Mal(Br2)-Aca can be used to connect MMAF and to synthesize ADC.

Mal(Br2)-Aca

Structure of 1443214-97-8

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ADC Linker
Molecular Formula
C10H11Br2NO4
Molecular Weight
369.01

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Synonyms
6-(3,4-Dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid; Dibromomaleimide-C5-COOH; DBM-C5-COOH
IUPAC Name
6-(3,4-dibromo-2,5-dioxopyrrol-1-yl)hexanoic acid
Canonical SMILES
C(CCC(=O)O)CCN1C(=O)C(=C(C1=O)Br)Br
InChI
InChI=1S/C10H11Br2NO4/c11-7-8(12)10(17)13(9(7)16)5-3-1-2-4-6(14)15/h1-5H2,(H,14,15)
InChIKey
XABAXSUMIXSPEP-UHFFFAOYSA-N
Density
1.952±0.06 g/cm3
Boiling Point
438.9±45.0 °C at 760 mmHg

Mal(Br2)-Aca is a chemical compound with potential applications in various scientific and industrial fields. Here are some key applications of Mal(Br2)-Aca:

Bioconjugation: Mal(Br2)-Aca can be used in bioconjugation techniques to link biomolecules, such as proteins or peptides, to other molecular entities. This process is essential for developing diagnostic assays, therapeutic agents, and targeted drug delivery systems. By conjugating specific molecules, researchers can enhance the specificity and efficacy of biotechnological products.

Proteomics Research: In proteomics, Mal(Br2)-Aca serves as a cross-linking agent to study protein-protein interactions. By introducing specific bonds between interacting proteins, researchers can map structural conformations and interaction networks. This information is crucial for understanding cellular processes and identifying potential targets for drug development.

Chemical Synthesis: Mal(Br2)-Aca is utilized in organic synthesis for modifying chemical structures. It can introduce functional groups or alter molecular frameworks, enabling the creation of novel compounds with desired properties. This capability is invaluable in designing new materials, pharmaceuticals, and other chemical products.

Material Science: In the field of material science, Mal(Br2)-Aca can be used to modify the surface properties of polymers and other materials. By attaching reactive groups, it enhances the material’s compatibility with biological systems or improves its chemical resistance. Such modifications can lead to the development of advanced materials for medical devices, coatings, and other applications.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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