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beta-Glc-TEG-Alkyne

  CAS No.: 1072903-76-4   Cat No.: BADC-01724 4.5  

beta-Glc-TEG-Alkyne is a glucose-functionalized ADC linker with TEG spacer and alkyne group for bioorthogonal click conjugation. It enhances solubility and site-specific payload attachment in antibody-drug conjugates. Keywords: ADC linker, glucose linker, TEG spacer, alkyne linker, click chemistry.

beta-Glc-TEG-Alkyne

Structure of 1072903-76-4

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ADC Linker
Molecular Formula
C15H26O9
Molecular Weight
350.36

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IUPAC Name
(2R,4R,5R)-2-(hydroxymethyl)-6-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]oxane-3,4,5-triol
Canonical SMILES
C#CCOCCOCCOCCOC1C(C(C(C(O1)CO)O)O)O
InChI
InChI=1S/C15H26O9/c1-2-3-20-4-5-21-6-7-22-8-9-23-15-14(19)13(18)12(17)11(10-16)24-15/h1,11-19H,3-10H2/t11-,12?,13-,14-,15?/m1/s1
InChIKey
IXCVCNLRVJBMIS-HNBOJAAESA-N

beta-Glc-TEG-Alkyne, a versatile chemical compound utilized in biochemistry and molecular biology, boasts a myriad of applications. Here are four key applications presented with high perplexity and burstiness:

Glycobiology: Serving as a cornerstone in the realm of glycobiology, beta-Glc-TEG-Alkyne plays a pivotal role in investigating the intricate structures of glycans and their biological functions. By integrating this compound into glycans, researchers can harness its potential to label and visualize sugars within cells using bioorthogonal click chemistry reactions. This innovative approach aids in unraveling complex glycosylation patterns and their profound implications in maintaining health and combating diseases.

Drug Delivery: Positioned at the forefront of drug delivery innovation, beta-Glc-TEG-Alkyne offers a pathway to developing targeted drug delivery systems. By conjugating therapeutic compounds with this versatile molecule, researchers can engineer drugs that possess the remarkable ability to target specific cells or tissues with precision. This targeted delivery mechanism not only enhances the efficacy of drugs but also minimizes undesirable side effects.

Bioconjugation: Renowned for its versatility, the alkyne group within beta-Glc-TEG-Alkyne emerges as a prime candidate for bioconjugation endeavors. Through the artful coupling of this compound with azide-containing molecules, stable triazole linkages can be readily formed. This sophisticated bioconjugation technique finds widespread applications in attaching a diverse array of biomolecules, such as proteins, antibodies, or other biological entities, to surfaces, probes, or nanoparticles, paving the way for groundbreaking advances in various biomedical fields.

Metabolic Labeling: Unleashing its potential in metabolic labeling, beta-Glc-TEG-Alkyne offers a gateway to tracking newly synthesized biomolecules within cellular metabolic pathways. As cells uptake and metabolize this compound, researchers can leverage click chemistry to detect and analyze intricate metabolic alterations. This technique proves invaluable in monitoring critical cellular processes, including growth, differentiation, and metabolic states, enabling a deeper understanding of complex biological systems.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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