Name: Me-Tet-PEG2-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

Methyltetrazine-CH2NHCO-PEG2-CH2CH2COOH

IUPAC Name

3-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]propanoic acid

Canonical SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCC(=O)O

InChI

InChI=1S/C18H23N5O5/c1-13-20-22-18(23-21-13)15-4-2-14(3-5-15)12-19-16(24)6-8-27-10-11-28-9-7-17(25)26/h2-5H,6-12H2,1H3,(H,19,24)(H,25,26)

InChIKey

FLJWYRUCTSWYAU-UHFFFAOYSA-N

Me-Tet-PEG2-COOH is a versatile chemical compound used in various bioconjugation and drug delivery applications. Here are some key applications of Me-Tet-PEG2-COOH:

Bioconjugation: Me-Tet-PEG2-COOH is utilized in bioconjugation processes where it serves as a linker to join proteins, peptides, or other biomolecules. The PEG (polyethylene glycol) moiety provides hydrophilicity, enhancing solubility and stability. This improves the functionality and bioactivity of therapeutics and diagnostic agents in biological environments.

Drug Delivery Systems: In the field of drug delivery, Me-Tet-PEG2-COOH is employed to design delivery vehicles that enhance the solubility and bioavailability of drugs. The PEGylation effect helps in reducing immunogenicity and prolonging the circulation half-life of drugs. This allows for the development of more effective and targeted pharmaceutical therapies.

Surface Modification: Me-Tet-PEG2-COOH can be used to modify the surfaces of nanoparticles and other materials to improve their biocompatibility. By attaching to these surfaces, it prevents protein adsorption and reduces non-specific interactions with biological systems. This is crucial in applications such as biosensors and medical implants, where minimizing immune responses is essential.

Research and Development: In research, Me-Tet-PEG2-COOH is a valuable tool for developing model systems to study the effects of PEGylation on biological interactions. It provides insights into how modifying biomolecules with PEG chains influences their behavior in biological assays. This application is fundamental for advancing the understanding of PEGylated compounds and designing new bioconjugation strategies.