Name: Me-Tet-PEG9-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Methyltetrazine-amino-PEG9-CH2CH2COOH

IUPAC Name

3-[2-[2-[2-[2-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Canonical SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

InChI

InChI=1S/C32H51N5O12/c1-27-34-36-32(37-35-27)29-4-2-28(3-5-29)26-33-30(38)6-8-41-10-12-43-14-16-45-18-20-47-22-24-49-25-23-48-21-19-46-17-15-44-13-11-42-9-7-31(39)40/h2-5H,6-26H2,1H3,(H,33,38)(H,39,40)

InChIKey

FODPVNVJILZXJT-UHFFFAOYSA-N

Density

1.200±0.06 g/cm3

Me-Tet-PEG9-COOH, a specialized polyethylene glycol derivative featuring a terminal carboxylic acid group, finds extensive use in bioconjugation and biomedical applications. Here are four key applications of Me-Tet-PEG9-COOH

Drug Delivery Systems: Leveraging the unique properties of Me-Tet-PEG9-COOH, researchers enhance the pharmacokinetics of drug molecules by boosting their solubility and stability. PEGylation of drugs contributes to extending their circulatory lifespan and diminishing immunogenic responses, thereby elevating their therapeutic efficacy. This attribute renders Me-Tet-PEG9-COOH indispensable for formulating enduring and precisely targeted therapeutic agents.

Bioconjugation: Embraced in bioconjugation chemistry, Me-Tet-PEG9-COOH serves as a pivotal agent for anchoring biomolecules like proteins and peptides onto diverse surfaces. The presence of a terminal carboxylic acid group facilitates covalent bonding with amine groups, fostering the creation of robust bioconjugates. This application is particularly instrumental in crafting cutting-edge diagnostic tools and biofunctionalized materials, pushing the boundaries of biotechnology forward.

Tissue Engineering: Within the realm of tissue engineering, Me-Tet-PEG9-COOH plays a crucial role in tailoring biomaterials to elevate their biocompatibility and functional attributes. By conjugating biomolecules onto scaffolds, it bolsters cell adhesion and proliferation, thereby nurturing tissue regeneration. This application stands as a linchpin in the development of engineered tissues and organs.

Surface Modification: Employing this compound for surface modification purposes, researchers alter the surfaces of nanoparticles and other materials to confer desired traits like hydrophilicity and resistance to protein adsorption. Such modifications are imperative in crafting materials for medical devices and implants, ensuring minimized undesired interactions and enhanced performance for biomedical applications.