MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH - CAS 2778374-70-0

MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH - CAS 2778374-70-0 Catalog number: BADC-01784

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MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH is an ADC linker that can be combined with the cytotoxic Camptothecin to form ADC-related drug-linker conjugates.

Category
ADCs Linker
Product Name
MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH
CAS
2778374-70-0
Catalog Number
BADC-01784
Molecular Formula
C31H40N6O10
Molecular Weight
656.68

Ordering Information

Catalog Number Size Price Quantity
BADC-01784 -- $-- Inquiry
Description
MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH is an ADC linker that can be combined with the cytotoxic Camptothecin to form ADC-related drug-linker conjugates.
IUPAC Name
2-cyclopropyl-2-[[[2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetic acid
Canonical SMILES
C1CC1C(C(=O)O)OCNC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)CCCCCN3C(=O)C=CC3=O
InChI
InChI=1S/C31H40N6O10/c38-23(9-5-2-6-14-37-27(42)12-13-28(37)43)32-16-24(39)33-18-26(41)36-22(15-20-7-3-1-4-8-20)30(44)34-17-25(40)35-19-47-29(31(45)46)21-10-11-21/h1,3-4,7-8,12-13,21-22,29H,2,5-6,9-11,14-19H2,(H,32,38)(H,33,39)(H,34,44)(H,35,40)(H,36,41)(H,45,46)/t22-,29?/m0/s1
InChIKey
SHKYFEZQVRQXHQ-RBQQCVMASA-N
Appearance
Off-white to light yellow Solid

MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH, a versatile chemical compound with diverse bioscience applications, serves as a key player in the following realms:

Drug Delivery Systems: Utilizing this compound as a linker or spacer in drug delivery systems allows for the controlled release of therapeutic agents. By fine-tuning the compound's structure, it can be customized to degrade at specific rates or in response to distinct biological conditions. This tailored approach enhances targeting precision and diminishes side effects in drug delivery applications, ultimately amplifying therapeutic efficacy.

Peptide Synthesis: Acting as a fundamental building block in peptide synthesis, MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH aids in the creation of cyclized peptides, renowned for their heightened stability and bioactivity. Cyclization plays a pivotal role in emulating natural peptides, fostering the development of peptide-based drugs with enhanced therapeutic potential. This application bears significant importance in both drug discovery endeavors and the formulation of novel biotherapeutics.

Cancer Research: Integrating the compound into anticancer research endeavors capitalizes on its capability to function as a prodrug component. This integration empowers the design of compounds that activate specifically within the tumor microenvironment, offering heightened efficacy and minimal toxicity. Targeted strategies of this nature are indispensable in propelling the field of precision medicine forward in the domain of cancer treatment.

Bioconjugation Studies: Within the realm of biotechnology, MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH plays a pivotal role in bioconjugation techniques, serving as a versatile molecular scaffold for linking biologically relevant moieties. This functionality enables the construction of multifunctional biomolecules tailored for diverse applications, such as imaging and therapeutic delivery.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records:
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