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Mal-L-Dap(Boc)-OH is an ADC linker featuring a maleimide (Mal) group for thiol-reactive conjugation and a Boc-protected side chain for orthogonal deprotection. It is primarily used to synthesize antibody-drug conjugates (ADCs) by enabling stable thiol-maleimide linkages with cysteine residues in antibodies, while the Boc group allows selective modification of the side chain. This compound is widely applied in targeted therapeutics and drug delivery systems, particularly in ADC development for cancer treatment.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00602 | -- | $-- | Inquiry |
Mal-L-PA-NH-Boc is a chemical compound used as a building block in peptide synthesis, offering various applications in biochemical research and pharmaceutical development. Here are some key applications of Mal-L-PA-NH-Boc:
Peptide Synthesis: Mal-L-PA-NH-Boc is widely used in the synthesis of peptides, where it acts as a protected amino acid derivative. It facilitates the construction of complex peptide chains by preventing side reactions during the coupling process. This makes it improtant for researchers developing therapeutic peptides and studying protein structure and function.
Drug Design and Development: This compound is instrumental in the development of peptide-based drugs, which are designed to target specific proteins or receptors in the body. By incorporating Mal-L-PA-NH-Boc into the drug design process, chemists can create peptides that exhibit desired biological activities with high specificity. It helps in optimizing drug candidates for enhanced efficacy and reduced side effects.
Bioconjugation Experiments: Mal-L-PA-NH-Boc is used in bioconjugation strategies to attach peptides to other molecules, such as drugs, dyes, or nanoparticles. This enables researchers to study cellular uptake, track peptide distribution in living systems, or enhance the therapeutic properties of a given molecule. The compound’s versatility in bioconjugation makes it essential for creating multifunctional biomolecules.
Protein Engineering: In protein engineering, Mal-L-PA-NH-Boc can be utilized to introduce non-natural amino acids into proteins, allowing for the exploration of novel functions and properties. This application is crucial for designing proteins with enhanced stability, activity, or specificity.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
