Name: Mal-L-Dap(Boc)-OH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

N-alpha-Maleimido-N-beta-Boc-L-2,3-diaminopropionic acid; Mal-Dpr(Boc); (S)-maleoyl-DPR(boc)-OH; 1H-Pyrrole-1-acetic acid, α-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2,5-dihydro-2,5-dioxo-, (αS)-; Mal-Dap(Boc); Mal-L-Dap(Boc)-OH; N-alpha-Maleimido-N-beta-t-butyloxycarbonyl-L-2,3-diaminopropionic acid; Mal-Dap(Boc)-OH; Mal-L-PA-NH-Boc; (αS)-α-[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-acetic acid; (S)-3-((tert-Butoxycarbonyl)amino)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid; (S)-3-(tert-Butoxycarbonylamino)-2-(maleimido)propanoic acid

IUPAC Name

(2S)-2-(2,5-dioxopyrrol-1-yl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

Canonical SMILES

CC(C)(C)OC(=O)NC[C@@H](C(=O)O)N1C(=O)C=CC1=O

InChI

InChI=1S/C12H16N2O6/c1-12(2,3)20-11(19)13-6-7(10(17)18)14-8(15)4-5-9(14)16/h4-5,7H,6H2,1-3H3,(H,13,19)(H,17,18)/t7-/m0/s1

InChIKey

QNSOCOXQLKMHCV-ZETCQYMHSA-N

Density

1.368±0.06 g/cm3

Appearance

White to off-white solid

Shipping

Room temperature, or blue ice upon request.

Storage

Store at 2-8 °C

Boiling Point

494.4±40.0 °C at 760 mmHg

Mal-L-PA-NH-Boc is a chemical compound used as a building block in peptide synthesis, offering various applications in biochemical research and pharmaceutical development. Here are some key applications of Mal-L-PA-NH-Boc:

Peptide Synthesis: Mal-L-PA-NH-Boc is widely used in the synthesis of peptides, where it acts as a protected amino acid derivative. It facilitates the construction of complex peptide chains by preventing side reactions during the coupling process. This makes it improtant for researchers developing therapeutic peptides and studying protein structure and function.

Drug Design and Development: This compound is instrumental in the development of peptide-based drugs, which are designed to target specific proteins or receptors in the body. By incorporating Mal-L-PA-NH-Boc into the drug design process, chemists can create peptides that exhibit desired biological activities with high specificity. It helps in optimizing drug candidates for enhanced efficacy and reduced side effects.

Bioconjugation Experiments: Mal-L-PA-NH-Boc is used in bioconjugation strategies to attach peptides to other molecules, such as drugs, dyes, or nanoparticles. This enables researchers to study cellular uptake, track peptide distribution in living systems, or enhance the therapeutic properties of a given molecule. The compound’s versatility in bioconjugation makes it essential for creating multifunctional biomolecules.

Protein Engineering: In protein engineering, Mal-L-PA-NH-Boc can be utilized to introduce non-natural amino acids into proteins, allowing for the exploration of novel functions and properties. This application is crucial for designing proteins with enhanced stability, activity, or specificity.