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MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH

  CAS No.: 2626930-84-3   Cat No.: BADC-01730 4.5  

MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH is an ADC linker that can be combined with the cytotoxic Camptothecin to form an ADC-related drug-linker conjugate.

MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH

Structure of 2626930-84-3

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ADC Linker
Molecular Formula
C31H40N6O10
Molecular Weight
656.68

* For research and manufacturing use only. We do not sell to patients.

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IUPAC Name
(2S)-2-cyclopropyl-2-[[[2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetic acid
Canonical SMILES
C1CC1C(C(=O)O)OCNC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)CCCCCN3C(=O)C=CC3=O
InChI
InChI=1S/C31H40N6O10/c38-23(9-5-2-6-14-37-27(42)12-13-28(37)43)32-16-24(39)33-18-26(41)36-22(15-20-7-3-1-4-8-20)30(44)34-17-25(40)35-19-47-29(31(45)46)21-10-11-21/h1,3-4,7-8,12-13,21-22,29H,2,5-6,9-11,14-19H2,(H,32,38)(H,33,39)(H,34,44)(H,35,40)(H,36,41)(H,45,46)/t22-,29-/m0/s1
InChIKey
SHKYFEZQVRQXHQ-ZTOMLWHTSA-N

MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH, a versatile compound with diverse applications in biotechnology and pharmaceuticals, serves as a foundation for innovative advancements.

Targeted Drug Delivery: Unveiling its potential in the realm of targeted drug delivery, MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH emerges as a pivotal component in crafting sophisticated drug delivery systems. Through its intricate structure, therapeutic agents can be intricately bound to specific targeting moieties, like antibodies, guiding them with precision to desired cells or tissues. This precision not only amplifies drug efficacy but also mitigates side effects, particularly evident in the realm of cancer therapies where precision is paramount.

Peptide Synthesis: Positioned as a cornerstone in peptide synthesis, MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH plays an indispensable role in constructing an array of peptides and peptidomimetics. Its distinct chemical architecture allows for the integration of cyclopropane rings, endowing peptides with rigidity and bolstering their structural stability.

Bioconjugation Techniques: Stepping into the realm of bioconjugation strategies, MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH emerges as a linchpin in facilitating the linkage of biomolecules, such as proteins, nucleic acids, or small molecules, with chemical probes or functional groups. The cyclopropane moiety provides a robust yet dynamic site for covalent attachment, ensuring stability in diagnostic assays, imaging modalities, and the intricate assembly of biomolecular structures.

Chemical Biology Research: In the dynamic arena of chemical biology research, MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH shines as a catalyst for investigating biochemical pathways and cellular processes. Through the strategic labeling and modification of proteins and biomolecules with this compound, researchers gain insight into intricate interactions and functions within biological systems. This investigative approach not only deepens our comprehension of cellular mechanisms but also unveils novel therapeutic targets.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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