Name: Amino-PEG2-t-butyl ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

Amino-PEG2-COOtBu; H2N-PEG2-CH2CH2COOtBu; tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate

IUPAC Name

tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate

Canonical SMILES

CC(C)(C)OC(=O)CCOCCOCCN

InChI

InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3

InChIKey

XIVHGTLMLORWEP-UHFFFAOYSA-N

Density

1.0±0.1 g/cm3

Solubility

10 mm in DMSO

Flash Point

103.3±18.7 °C

Index Of Refraction

1.450

PSA

70.78000

Vapor Pressure

0.0±0.7 mmHg at 25°C

Appearance

Colorless to light yellow clear liquid

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -5 °C, keep in dry and avoid sunlight.

Pictograms

Corrosive; Irritant

Signal Word

Danger

Boiling Point

313.7±22.0 °C at 760 mmHg

Form

Liquid

Biological Activity

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]

Amino-PEG2-t-butyl ester, a versatile chemical compound with wide-ranging applications in biochemistry and medicine, is employed in diverse ways. Here are four key applications articulated with a high level of perplexity and burstiness:

Drug Delivery: Serving as a pivotal linker in drug conjugate synthesis, Amino-PEG2-t-butyl ester plays a significant role in enhancing the solubility, stability, and pharmacokinetic properties of therapeutic agents. By tethering drugs to the PEG moiety, formulations can achieve targeted delivery and reduced side effects, revolutionizing the landscape of pharmaceutical development.

Bioconjugation: In the intricate realm of bioconjugation, Amino-PEG2-t-butyl ester emerges as a crucial tool for conjugating biomolecules like antibodies, peptides, and proteins. The flexible PEG linker minimizes steric hindrance, enabling efficient binding and functionalization, thereby empowering the creation of cutting-edge biotechnological instruments and biosensors.

Surface Modification: Amino-PEG2-t-butyl ester finds utility in the modification of nanoparticle surfaces, medical devices, and diagnostic tools. The process of PEGylation helps in reducing non-specific interactions and enhancing biocompatibility, fostering the development of medical implants and diagnostic assays with heightened specificity and minimal immunogenic responses, contributing to advancements in medical technology.

Proteomics: Within the realm of proteomic studies, Amino-PEG2-t-butyl ester proves invaluable for chemically modifying proteins, facilitating purification, labeling, and functional investigations. The selective processing of the ester group reveals free amines for subsequent reactions, enabling detailed exploration of protein-protein interactions, structural biology, and functional proteomics, shedding light on the intricate workings of biological systems.