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CAS No.: 756526-06-4
Cat No.: BADC-01155
Purity: ≥95%
4.5 
Amino-PEG8-t-butyl ester is a versatile ADC linker intermediate featuring PEG8 spacer for improved solubility and flexibility in antibody-drug conjugates development and targeted drug delivery applications.
Structure of 756526-06-4
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Amino-PEG8-t-butyl ester, a versatile reagent with multifaceted applications in biochemical and biotechnological realms, is highly esteemed for its diverse functionalities. Here are four key applications of Amino-PEG8-t-butyl ester:
Drug Delivery: Delving into the domain of drug delivery systems, Amino-PEG8-t-butyl ester emerges as a pivotal player in enhancing the solubility and stability of pharmaceutical compounds. Through the conjugation of drugs with this PEGylation reagent, researchers embark on a journey to augment the bioavailability and therapeutic efficacy of medicinal agents. This strategy proves particularly efficacious for delivering hydrophobic drugs while mitigating their systemic toxicity.
Protein Conjugation: Within the realm of protein research, Amino-PEG8-t-butyl ester assumes a critical role as a linker, facilitating the attachment of polyethylene glycol (PEG) to proteins, thereby ameliorating their solubility and diminishing immunogenicity. PEGylation, mediated by Amino-PEG8-t-butyl ester, extends the half-life of therapeutic proteins circulating in the bloodstream, heralding a boon in the realm of protein-based drugs and diagnostic reagents.
Surface Modification: Unlocking the potential of surface modification, Amino-PEG8-t-butyl ester emerges as a keystone reagent for altering the surfaces of nanoparticles, biomaterials, and medical devices. By affixing PEG chains to these surfaces, scientists embark on a quest to impede protein adsorption and cellular attachment, thereby mitigating biofouling and elevating biocompatibility levels.
Bioconjugation Chemistry: Embarking on a journey into bioconjugation chemistry, Amino-PEG8-t-butyl ester stands as a crucial linchpin connecting various biomolecules such as antibodies, peptides, and nucleic acids. The PEG spacer integrated through this reagent elevates the stability and functionality of conjugated biopolymers, underscoring its importance in the development of targeted therapeutics, biosensors, and diagnostic assays.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00915 | Amino-PEG6-t-butyl ester | 1286281-32-0 | |
| BADC-01152 | Amino-PEG2-t-butyl ester | 756525-95-8 |
Amino-PEG8-t-butyl ester
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Amino-PEG8-t-butyl ester
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