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Indole-C2-amide-C2-NH2

  CAS No.: 215789-29-0   Cat No.: BADC-01649 4.5  

Indole-C2-amide-C2-NH2 is an indole-derived ADC linker intermediate featuring amide and amine groups, enabling versatile conjugation strategies for antibody-drug conjugates with enhanced payload stability. Keywords: ADC linker, indole linker, amide group, amine group, payload conjugation.

Indole-C2-amide-C2-NH2

Structure of 215789-29-0

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ADC Linker
Molecular Formula
C13H17N3O
Molecular Weight
231.29

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Synonyms
Propanamide, 3-amino-N-[2-(1H-indol-3-yl)ethyl]-
IUPAC Name
3-amino-N-[2-(1H-indol-3-yl)ethyl]propanamide
Canonical SMILES
C1=CC=C2C(=C1)C(=CN2)CCNC(=O)CCN
InChI
InChI=1S/C13H17N3O/c14-7-5-13(17)15-8-6-10-9-16-12-4-2-1-3-11(10)12/h1-4,9,16H,5-8,14H2,(H,15,17)
InChIKey
ANPPXRSQOVOACQ-UHFFFAOYSA-N

Indole-C2-amide-C2-NH2 is a small organic molecule with versatile applications in biochemistry and molecular biology. Here are some key applications of Indole-C2-amide-C2-NH2:

1. Drug Discovery: Indole-C2-amide-C2-NH2 serves as a useful scaffold in medicinal chemistry for the development of new therapeutic agents. Its structure allows for modifications to improve pharmacokinetic properties and bioactivity. Researchers can design derivatives to target specific enzymes or receptors, potentially leading to new treatments for various diseases.

2. Chemical Biology: This compound can be utilized as a probe to study biological systems and mechanisms. Indole-C2-amide-C2-NH2 can interact with specific proteins or nucleic acids, providing insights into their functions and interactions. This helps in elucidating cellular pathways and identifying molecular targets for drug development.

3. Fluorescent Labeling: Indole-C2-amide-C2-NH2 derivatives can be employed in the development of fluorescent dyes and labels. These fluorescent probes are essential for imaging and tracking biomolecules in live cells and tissues. By attaching these derivatives to proteins or nucleic acids, researchers can visualize cellular processes in real-time.

4. Enzyme Inhibition Studies: Indole-C2-amide-C2-NH2 can act as a potent inhibitor for certain enzymes, making it valuable in enzymology research. By inhibiting specific enzymatic activities, scientists can study the role of these enzymes in metabolic and signaling pathways. This information is crucial in understanding disease mechanisms and developing targeted therapies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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