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10-Undecynoyl-OSu

  CAS No.: 1006592-57-9   Cat No.: BADC-01704 4.5  

10-Undecynoyl-OSu is an alkyne-functionalized NHS ester ADC linker intermediate for efficient amine-reactive conjugation and click chemistry in antibody-drug conjugates, supporting site-specific payload attachment. Keywords: ADC linker, alkyne linker, NHS ester, amine-reactive, click chemistry.

10-Undecynoyl-OSu

Structure of 1006592-57-9

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ADC Linker
Molecular Formula
C15H21NO4
Molecular Weight
279.33

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Synonyms
10-undecynoic acid succinimidyl ester
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) undec-10-ynoate
Canonical SMILES
C#CCCCCCCCCC(=O)ON1C(=O)CCC1=O
InChI
InChI=1S/C15H21NO4/c1-2-3-4-5-6-7-8-9-10-15(19)20-16-13(17)11-12-14(16)18/h1H,3-12H2
InChIKey
PUOUPBMTHXHXBB-UHFFFAOYSA-N

10-Undecynoyl-OSu is a versatile chemical reagent used for attaching functional groups to biomolecules. Here are some key applications of 10-Undecynoyl-OSu:

Protein Labeling: 10-Undecynoyl-OSu is frequently used in protein engineering to attach fluorescent tags or other functional groups to proteins. This allows researchers to visualize and track proteins within biological systems using fluorescence microscopy or other detection methods. The ability to precisely label proteins helps in studying protein localization, interactions, and dynamics.

Drug Delivery Studies: By chemically modifying drug molecules with 10-Undecynoyl-OSu, researchers can enhance the drug’s stability, solubility, or targeted delivery. This modification enables the effective conjugation of drugs to carrier molecules such as nanoparticles or liposomes. As a result, it is possible to improve drug efficacy, reduce side effects, and achieve controlled release profiles.

Biomaterial Functionalization: 10-Undecynoyl-OSu is used to functionalize surfaces of biomaterials such as hydrogels, nanoparticles, and implantable devices with bioactive molecules. This chemical modification can enhance biocompatibility, promote cell attachment, or deliver therapeutic agents. Functionalized biomaterials are pivotal in tissue engineering, regenerative medicine, and diagnostic applications.

Nucleic Acid Research: In nucleic acid studies, 10-Undecynoyl-OSu can be employed to attach various biochemical moieties to DNA or RNA. This allows for the creation of nucleic acid probes, sensors, or aptamers with enhanced properties. These modified nucleic acids are instrumental in detecting specific sequences, probing gene regulation, and developing novel diagnostic tools.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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