Me-Tet-PEG4-NHS - CAS 2143968-22-1

Me-Tet-PEG4-NHS - CAS 2143968-22-1 Catalog number: BADC-01822

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Me-Tet-PEG4-NHS is an ADC linker containing 4 PEG units.

Category
ADCs Linker
Product Name
Me-Tet-PEG4-NHS
CAS
2143968-22-1
Catalog Number
BADC-01822
Molecular Formula
C26H34N6O9
Molecular Weight
574.58

Ordering Information

Catalog Number Size Price Quantity
BADC-01822 -- $-- Inquiry
Description
Me-Tet-PEG4-NHS is an ADC linker containing 4 PEG units.
Synonyms
Methyltetrazine-amino-PEG4-CH2CH2COONHS
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O
InChI
InChI=1S/C26H34N6O9/c1-19-28-30-26(31-29-19)21-4-2-20(3-5-21)18-27-22(33)8-10-37-12-14-39-16-17-40-15-13-38-11-9-25(36)41-32-23(34)6-7-24(32)35/h2-5H,6-18H2,1H3,(H,27,33)
InChIKey
LGEMLJPCMGRIMC-UHFFFAOYSA-N

Me-Tet-PEG4-NHS, a versatile chemical linker in bioconjugation and pharmaceutical research, finds diverse applications in the following areas:

Bioconjugation: Me-Tet-PEG4-NHS plays a pivotal role in bioconjugation techniques by covalently connecting biomolecules like antibodies, proteins, or peptides to various molecules or surfaces. This linker enables the creation of stable conjugates that maintain the biological activity of the attached molecules, essential for the development of cutting-edge diagnostic tools and therapeutics with enhanced stability and functionality.

Drug Delivery: In the realm of pharmaceuticals, Me-Tet-PEG4-NHS stands out as a valuable tool for modifying drug molecules or delivery systems to improve their solubility and circulation time. By attaching PEG chains via this linker, drugs can evade rapid immune clearance, leading to enhanced bioavailability and therapeutic efficacy. This strategy is particularly advantageous for crafting long-acting and targeted drug delivery systems.

Surface Coating: Me-Tet-PEG4-NHS finds application in surface modification techniques to boost the biocompatibility and reduce nonspecific binding of medical devices and biointerfaces. Through PEG coating, this linker assists in creating a hydrophilic shield that minimizes protein adsorption and cellular adhesion, crucial in the development of implants, biosensors, and other biomedical devices aiming for reduced fouling, marking a significant leap in surface engineering technology.

Molecular Probes: Researchers harness Me-Tet-PEG4-NHS to synthesize molecular probes for imaging and diagnostic purposes. By conjugating fluorescent dyes, radiolabels, or other reporter molecules, scientists engineer sensitive detection tools for monitoring biological processes both in vivo and in vitro. This application plays a pivotal role in advancing imaging techniques and elevating the precision of molecular diagnostics, laying the groundwork for breakthroughs in healthcare technology.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Me-Tet-PEG4-NHS
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