Name: Me-Tet-PEG4-NHS
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

Methyltetrazine-amino-PEG4-CH2CH2COONHS

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O

InChI

InChI=1S/C26H34N6O9/c1-19-28-30-26(31-29-19)21-4-2-20(3-5-21)18-27-22(33)8-10-37-12-14-39-16-17-40-15-13-38-11-9-25(36)41-32-23(34)6-7-24(32)35/h2-5H,6-18H2,1H3,(H,27,33)

InChIKey

LGEMLJPCMGRIMC-UHFFFAOYSA-N

Me-Tet-PEG4-NHS, a versatile chemical linker in bioconjugation and pharmaceutical research, finds diverse applications in the following areas:

Bioconjugation: Me-Tet-PEG4-NHS plays a pivotal role in bioconjugation techniques by covalently connecting biomolecules like antibodies, proteins, or peptides to various molecules or surfaces. This linker enables the creation of stable conjugates that maintain the biological activity of the attached molecules, essential for the development of cutting-edge diagnostic tools and therapeutics with enhanced stability and functionality.

Drug Delivery: In the realm of pharmaceuticals, Me-Tet-PEG4-NHS stands out as a valuable tool for modifying drug molecules or delivery systems to improve their solubility and circulation time. By attaching PEG chains via this linker, drugs can evade rapid immune clearance, leading to enhanced bioavailability and therapeutic efficacy. This strategy is particularly advantageous for crafting long-acting and targeted drug delivery systems.

Surface Coating: Me-Tet-PEG4-NHS finds application in surface modification techniques to boost the biocompatibility and reduce nonspecific binding of medical devices and biointerfaces. Through PEG coating, this linker assists in creating a hydrophilic shield that minimizes protein adsorption and cellular adhesion, crucial in the development of implants, biosensors, and other biomedical devices aiming for reduced fouling, marking a significant leap in surface engineering technology.

Molecular Probes: Researchers harness Me-Tet-PEG4-NHS to synthesize molecular probes for imaging and diagnostic purposes. By conjugating fluorescent dyes, radiolabels, or other reporter molecules, scientists engineer sensitive detection tools for monitoring biological processes both in vivo and in vitro. This application plays a pivotal role in advancing imaging techniques and elevating the precision of molecular diagnostics, laying the groundwork for breakthroughs in healthcare technology.