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Me-Tet-PEG4-NHS

  CAS No.: 2143968-22-1   Cat No.: BADC-01822 4.5  

Me-Tet-PEG4-NHS is a methyl-tetrazine functionalized PEG4 NHS ester ADC linker designed for fast amine-reactive conjugation and stable payload attachment in antibody-drug conjugates. Keywords: ADC linker, methyl-tetrazine linker, PEG spacer, NHS ester, bioorthogonal chemistry.

Me-Tet-PEG4-NHS

Structure of 2143968-22-1

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ADC Linker
Molecular Formula
C26H34N6O9
Molecular Weight
574.58

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
Methyltetrazine-amino-PEG4-CH2CH2COONHS
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O
InChI
InChI=1S/C26H34N6O9/c1-19-28-30-26(31-29-19)21-4-2-20(3-5-21)18-27-22(33)8-10-37-12-14-39-16-17-40-15-13-38-11-9-25(36)41-32-23(34)6-7-24(32)35/h2-5H,6-18H2,1H3,(H,27,33)
InChIKey
LGEMLJPCMGRIMC-UHFFFAOYSA-N

Me-Tet-PEG4-NHS, a versatile chemical linker in bioconjugation and pharmaceutical research, finds diverse applications in the following areas:

Bioconjugation: Me-Tet-PEG4-NHS plays a pivotal role in bioconjugation techniques by covalently connecting biomolecules like antibodies, proteins, or peptides to various molecules or surfaces. This linker enables the creation of stable conjugates that maintain the biological activity of the attached molecules, essential for the development of cutting-edge diagnostic tools and therapeutics with enhanced stability and functionality.

Drug Delivery: In the realm of pharmaceuticals, Me-Tet-PEG4-NHS stands out as a valuable tool for modifying drug molecules or delivery systems to improve their solubility and circulation time. By attaching PEG chains via this linker, drugs can evade rapid immune clearance, leading to enhanced bioavailability and therapeutic efficacy. This strategy is particularly advantageous for crafting long-acting and targeted drug delivery systems.

Surface Coating: Me-Tet-PEG4-NHS finds application in surface modification techniques to boost the biocompatibility and reduce nonspecific binding of medical devices and biointerfaces. Through PEG coating, this linker assists in creating a hydrophilic shield that minimizes protein adsorption and cellular adhesion, crucial in the development of implants, biosensors, and other biomedical devices aiming for reduced fouling, marking a significant leap in surface engineering technology.

Molecular Probes: Researchers harness Me-Tet-PEG4-NHS to synthesize molecular probes for imaging and diagnostic purposes. By conjugating fluorescent dyes, radiolabels, or other reporter molecules, scientists engineer sensitive detection tools for monitoring biological processes both in vivo and in vitro. This application plays a pivotal role in advancing imaging techniques and elevating the precision of molecular diagnostics, laying the groundwork for breakthroughs in healthcare technology.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Me-Tet-PEG4-COOH | Cyclooctyne-O-amido-PEG4-NHS ester | Propargyl-PEG5-amine | ethyl azetidine-3-carboxylate hydrochloride | Propargyl-PEG2-amine | Me-Tet-PEG4-NHS
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