Name: Me-Tet-PEG5-NHS
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Methyltetrazine-amido-PEG5-NHS ester; Methyltetrazine-amino-PEG5-CH2CH2COONHS

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O

InChI

InChI=1S/C28H38N6O10/c1-21-30-32-28(33-31-21)23-4-2-22(3-5-23)20-29-24(35)8-10-39-12-14-41-16-18-43-19-17-42-15-13-40-11-9-27(38)44-34-25(36)6-7-26(34)37/h2-5H,6-20H2,1H3,(H,29,35)

InChIKey

WIMBDRIDFKMKOO-UHFFFAOYSA-N

Me-Tet-PEG5-NHS, a versatile chemical compound utilized in bioconjugation and biomedical research, finds diverse applications across various domains.

Protein Modification: Embracing Me-Tet-PEG5-NHS in protein engineering, researchers selectively adorn proteins with polyethylene glycol (PEG) chains, a process termed PEGylation. This strategic modification elevates protein stability, solubility, and resistance to proteolytic degradation, essential for refining therapeutic proteins with enhanced pharmacokinetics and reduced immunogenicity.

Antibody Conjugation: In the realm of antibody-based research, Me-Tet-PEG5-NHS serves as a pivotal tool for conjugating antibodies with diverse labels, such as fluorescent dyes or drug molecules. Through these conjugations, researchers fashion targeted imaging probes or antibody-drug conjugates, catering to diagnostic and therapeutic endeavors. This precision ensures directed delivery of therapeutic agents to afflicted cells, mitigating off-target repercussions.

Nanoparticle Functionalization: Leveraging Me-Tet-PEG5-NHS, scientists embellish nanoparticles with PEG and other bioactive molecules, boosting their biocompatibility and circulation duration in vivo. This enhancement renders the nanoparticles apt for drug delivery and imaging undertakings. Tailored nanoparticles can be crafted to zero in on specific tissues or cell types, maximizing the efficacy of therapeutic interventions.

Biosensor Development: Within the landscape of biosensor fabrication, Me-Tet-PEG5-NHS plays a pivotal role in surface modification with PEG to combat nonspecific binding. This strategic maneuver results in the creation of highly sensitive and selective biosensors, vital for detecting biomolecules in intricate samples. These advanced biosensors are indispensable for myriad applications, spanning medical diagnostics, environmental monitoring, and food safety evaluations.