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Fmoc-Gly-Gly-D-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OH is the D-isomer of Fmoc-Gly-Gly-Phe-OH (HY-131833).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01261 | -- | $-- | Inquiry |
Fmoc-Gly-Gly-D-Phe-OH, a versatile peptide synthesis reagent utilized in the fields of biochemistry and molecular biology, boasts diverse applications. Here are four key applications:
Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis (SPPS), Fmoc-Gly-Gly-D-Phe-OH acts as a crucial building block. Its Fmoc protective group ensures stability throughout the chain elongation process, enabling the precise construction of intricate peptide sequences. This method facilitates the generation of highly purified peptides tailored for both research purposes and therapeutic applications.
Drug Development: In the realm of drug discovery, Fmoc-Gly-Gly-D-Phe-OH plays a pivotal role in synthesizing peptide-based drug candidates. These peptides can mimic crucial protein-protein interactions or regulate biological pathways, offering innovative therapeutic avenues for combating diseases like cancer, diabetes, and infectious ailments. Custom peptides synthesized using Fmoc-Gly-Gly-D-Phe-OH can be fine-tuned for enhanced potency, selectivity, and stability, propelling pharmaceutical advancements.
Structural Biology: Researchers harness the power of Fmoc-Gly-Gly-D-Phe-OH to fabricate peptide probes and models essential for investigating protein structure and function. These synthetic peptides find utility in techniques such as X-ray crystallography and NMR spectroscopy, aiding in the comprehensive exploration of protein folding and intermolecular interactions. Understanding these intricate structural nuances is imperative for informed drug design strategies and innovative protein engineering endeavors.
Bioconjugation: Functioning as a versatile linker or spacer, Fmoc-Gly-Gly-D-Phe-OH contributes to the creation of bioconjugates where peptides are conjugated to diverse molecules like drugs, fluorophores, or antibodies. This bioconjugation process is indispensable for crafting advanced diagnostic tools and targeted therapies. The presence of D-Phe enhances the stability and bioavailability of the conjugated peptides in clinical and research settings.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
