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DBCO-Val-Cit-PABC-PNP

  CAS No.:   Cat No.: BADC-01257   Purity: > 99% 4.5  

DBCO-Val-Cit-PABC-PNP is a reactive ADC linker featuring DBCO for click chemistry and PNP active ester for amine coupling, enabling precise antibody-drug conjugate assembly with cleavable payload release.

DBCO-Val-Cit-PABC-PNP

Structure of

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ADC Linker
Molecular Formula
C46H49N7O10
Molecular Weight
859.92
Shipping
Room temperature
Shipping
-20°C

* For research and manufacturing use only. We do not sell to patients.

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Capabilities & Facilities

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IUPAC Name
Solubility
10 mm in DMSO
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
-20°C

DBCO-Val-Cit-PABC-PNP is a compound used in bioconjugation and drug delivery applications, exploiting its unique chemical and biological properties. Here are some key applications of DBCO-Val-Cit-PABC-PNP:

Antibody-Drug Conjugates (ADCs): DBCO-Val-Cit-PABC-PNP is commonly used in the synthesis of antibody-drug conjugates, where it serves as a linker to attach cytotoxic drugs to antibodies. This enables the targeted delivery of chemotherapy agents specifically to cancer cells, minimizing off-target effects and improving therapeutic efficacy. The stability and cleavability of the Val-Cit linker ensure the release of the drug within the tumor microenvironment.

Click Chemistry: The DBCO moiety in DBCO-Val-Cit-PABC-PNP makes it an ideal reagent for click chemistry reactions, particularly in bioorthogonal conjugation. This allows for the specific and efficient labeling of biomolecules in a controlled manner, facilitating the study of complex biological systems. The use of click chemistry with DBCO-Val-Cit-PABC-PNP is highly valuable in proteomics, cell imaging, and diagnostics.

Targeted Drug Delivery: By incorporating DBCO-Val-Cit-PABC-PNP into prodrug systems, researchers can achieve targeted drug delivery with precise control over drug activation. The Val-Cit dipeptide linker is enzymatically cleavable, ensuring the release of the active drug in specific cellular environments, such as tumor tissues. This strategy enhances the therapeutic index and reduces the systemic toxicity of potent drugs.

Bioconjugation: DBCO-Val-Cit-PABC-PNP is extensively utilized in bioconjugation for tagging and modifying proteins, peptides, and other biomolecules. The DBCO group allows for robust and selective conjugation to azide-functionalized molecules under mild conditions. This application is critical in the development of novel biotherapeutics, biosensors, and in various diagnostic procedures.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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