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Me-Tet-PEG2-NHS

  CAS No.: 2740357-12-2   Cat No.: BADC-01817 4.5  

Me-Tet-PEG2-NHS is a methyl-tetrazine PEG2 NHS ester ADC linker facilitating rapid and stable bioorthogonal conjugation for efficient payload delivery in antibody-drug conjugates. Keywords: ADC linker, methyl-tetrazine linker, PEG spacer, NHS ester, click chemistry.

Me-Tet-PEG2-NHS

Structure of 2740357-12-2

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ADC Linker
Molecular Formula
C23H28N6O7
Molecular Weight
500.50

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
Methyltetrazine-amino-PEG2-CH2CH2COONHS
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 4-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]butanoate
Canonical SMILES
CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCCC(=O)ON3C(=O)CCC3=O
InChI
InChI=1S/C23H28N6O7/c1-16-25-27-23(28-26-16)18-6-4-17(5-7-18)15-24-19(30)10-12-35-14-13-34-11-2-3-22(33)36-29-20(31)8-9-21(29)32/h4-7H,2-3,8-15H2,1H3,(H,24,30)
InChIKey
OEEQATCXRQNWEF-UHFFFAOYSA-N

Me-Tet-PEG2-NHS, a versatile bifunctional linker, plays a crucial role in bioconjugation and the advancement of cutting-edge biomedical applications. Here are four key applications of Me-Tet-PEG2-NHS:

Protein Labeling: A cornerstone application of Me-Tet-PEG2-NHS lies in protein labeling, where its prowess in attaching fluorescent dyes or other markers to proteins reigns supreme. The NHS ester engages with primary amines on proteins, facilitating precise labeling essential for tracking protein interactions, localizing proteins, and quantifying protein expression across diverse biological assays.

Drug Delivery Systems: Delving into the realm of drug delivery systems, Me-Tet-PEG2-NHS emerges as a vital linker in the conjugation of therapeutic agents with targeting molecules. By bridging drugs with antibodies or peptides, it amplifies their specificity and efficacy, thereby refining pharmacokinetics and diminishing side effects to render treatments safer and more potent.

Bioconjugation for Diagnostics: Unveiling its prowess in diagnostic tool creation, Me-Tet-PEG2-NHS aids in immobilizing biomolecules onto biosensor surfaces. The PEG spacer delivers the perfect balance of flexibility, minimizing steric hindrance, and enhancing biomolecule accessibility. This empowers the development of highly sensitive and specific diagnostic assays geared towards detecting biomarkers with unparalleled precision.

PEGylation: Me-Tet-PEG2-NHS assumes a pivotal role in the transformative process of PEGylation, where polyethylene glycol (PEG) is bonded to biomolecules to elevate their properties. This modification can boost a molecule's solubility, stability, and half-life, particularly beneficial in the realm of therapeutic protein and peptide development.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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