Name: Aminoxyacetamide-PEG3-azide
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Aminoxyacetamide-PEG3-azide; N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]-2-(aminooxy)acetamide

IUPAC Name

2-aminooxy-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]acetamide

Canonical SMILES

C(COCCOCCOCCN=[N+]=[N-])NC(=O)CON

InChI

InChI=1S/C10H21N5O5/c11-15-14-2-4-18-6-8-19-7-5-17-3-1-13-10(16)9-20-12/h1-9,12H2,(H,13,16)

InChIKey

XAZLOCGDVCWCCY-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Appearance

Solid

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Form

Solid

Aminoxyacetamide-PEG3-azide, a highly versatile compound utilized in bioconjugation and molecular labeling, boasts a myriad of applications. Here are four key applications of Aminoxyacetamide-PEG3-azide:

Bioconjugation: Central to bioconjugation methodologies, Aminoxyacetamide-PEG3-azide plays a pivotal role in linking diverse biomolecules, like proteins and peptides, to surfaces or other molecular entities. This compound enables the formation of stable oxime linkages, crucial for generating functionalized bioconjugates utilized in an array of applications, spanning from drug delivery systems to biosensors and diagnostic assays.

Molecular Labeling: Within the realm of molecular biology, Aminoxyacetamide-PEG3-azide facilitates the precise labeling of biomolecules with fluorescent tags or other reporter moieties. Thanks to its azide group, this compound engages in click chemistry reactions, enabling accurate and efficient labeling processes essential for imaging studies aimed at unraveling intricate cellular processes that necessitate the visualization of specific biomolecules.

Protein Modification: Leveraged for protein modification, Aminoxyacetamide-PEG3-azide serves as a key player in attaching polyethylene glycol (PEG) chains to proteins, enhancing their solubility and stability. The PEG3 spacer confers flexibility and diminishes steric hindrance, making it an ideal candidate for conjugating functional groups to proteins. Such modifications are frequently employed to ameliorate the pharmacokinetics and therapeutic potency of protein-based pharmaceuticals, ushering in advanced treatment modalities.

Surface Functionalization: Embracing the realm of bioengineering, Aminoxyacetamide-PEG3-azide offers a pathway for surface functionalization across diverse applications. By tethering biomolecules to surfaces, researchers can fashion biosensors, microarrays, and cell culture platforms that foster enhanced interactions between the surface and biological entities, culminating in more precise and efficient biological assays.