Exatecan hydrochloride - CAS 144008-87-7

Exatecan hydrochloride - CAS 144008-87-7 Catalog number: BADC-01405

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Exatecan hydrochloride is the salt of Exatecan, which is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan is an inhibitor of DNA topoisomerase I.

Category
ADCs Cytotoxin
Product Name
Exatecan hydrochloride
CAS
144008-87-7
Catalog Number
BADC-01405
Molecular Formula
C24H22FN3O4.HCl
Molecular Weight
471.91
Exatecan hydrochloride

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BADC-01405 -- $--
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Description
Exatecan hydrochloride is the salt of Exatecan, which is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan is an inhibitor of DNA topoisomerase I.
Synonyms
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, monohydrochloride, (1S,9S)-; 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, monohydrochloride, (1S-trans)-; DX 8951a; (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione hydrochloride (1:1)
IUPAC Name
(10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;hydrochloride
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O.Cl
InChI
InChI=1S/C24H22FN3O4.ClH/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H/t16-,24-;/m0./s1
InChIKey
LKVSRDWTZFISCX-GRGFAMGGSA-N
Purity
≥95%
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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