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CAS No.: 2246380-69-6
Cat No.: BADC-00666
4.5 
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.
Structure of 2246380-69-6
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MAC glucuronide phenol-linked SN-38 is a defined ADC Cytotoxin with Linker designed for targeted delivery of SN-38, the active metabolite of irinotecan. This construct uses a glucuronide-based phenol-linked ADC Linker, providing stability in circulation and efficient intracellular release of the ADC payload. As a potent ADC Cytotoxin, it enables selective delivery of SN-38 to antigen-expressing tumor cells, facilitating DNA topoisomerase I inhibition and subsequent apoptosis with controlled release through the cleavable linker.
The mechanism of MAC glucuronide phenol-linked SN-38 relies on antibody-mediated binding to tumor-specific antigens, followed by internalization into malignant cells. Within lysosomes, the glucuronide linker is cleaved by β-glucuronidase, releasing SN-38 directly inside the cell. This selective release ensures the ADC payload exerts its cytotoxic effect specifically in tumor cells, maintaining potent activity while minimizing systemic exposure. The phenol-linked design provides predictable cleavage kinetics and reproducible payload activation.
MAC glucuronide phenol-linked SN-38 allows stable conjugation to monoclonal antibodies, generating homogeneous ADC Cytotoxins with Linker. The glucuronide-based cleavable linker ensures reliable intracellular payload release and preserves the activity of SN-38. Its chemical structure, solubility, and linker stability support consistent ADC assembly, enabling precise intracellular delivery of the cytotoxic agent while maintaining overall ADC integrity.
Applications of MAC glucuronide phenol-linked SN-38 focus on its function as a defined ADC payload-linker combination for constructing homogeneous antibody-drug conjugates. The β-glucuronidase-cleavable linker facilitates controlled release of SN-38 inside tumor cells, producing consistent topoisomerase I inhibition and cytotoxicity. This reagent is essential for generating ADC Cytotoxins with Linker that achieve targeted DNA damage, supporting precision oncology research and development of highly potent, tumor-selective therapeutics.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00847 | CL2-SN-38 | 1036969-20-6 | |
| BADC-00742 | CL2A-SN 38 | 1279680-68-0 | |
| BADC-01452 | MC-SN38 | 1473403-87-0 | |
| BADC-00854 | Mc-VC-PAB-SN38 | 1801838-28-7 | |
| BADC-00667 | MAC glucuronide α-hydroxy lactone-linked SN-38 | 2246380-70-9 | |
| BADC-01393 | Irinotecan EP Impurity E (SN-38) | 86639-52-3 | |
| BADC-01425 | NH2-PEG4-VC-PAB-DMEA-SN38 | ||
| BADC-01626 | CL2A-SN-38 DCA |
What is MAC glucuronide phenol-linked SN-38?
MAC glucuronide phenol-linked SN-38 is an ADC payload where SN-38, the active metabolite of irinotecan, is linked via a glucuronide-protected phenol to a macromolecular carrier. This design allows controlled release of SN-38 upon enzymatic cleavage in target cells.
10/11/2022
Could you explain how the glucuronide phenol linkage controls SN-38 release?
The glucuronide moiety is cleaved by β-glucuronidase enzymes overexpressed in tumor environments, triggering phenol self-immolation and releasing the active SN-38 molecule selectively within cancer cells.
17/12/2022
We would like to understand the advantages of using SN-38 in ADCs.
SN-38 is a topoisomerase I inhibitor with high cytotoxic potency. Linking it via MAC glucuronide phenol enables selective delivery, improving therapeutic index while reducing systemic exposure and toxicity in preclinical models.
30/3/2016
Is MAC glucuronide phenol-linked SN-38 suitable for use in solid tumor models?
Yes, the payload is specifically designed for solid tumor targeting where β-glucuronidase activity is high, allowing selective activation and release of SN-38 within tumor tissues for enhanced efficacy.
8/6/2016
Dear team, what is the primary application of this payload in research studies?
This payload is used in ADC development for evaluating enzyme-triggered release, cytotoxic efficacy, pharmacokinetics, and tumor-targeted delivery in preclinical oncology studies.
26/6/2019
— Dr. Isabelle Martin, ADC Scientist (France)
MAC glucuronide phenol-linked SN-38 linker allowed smooth conjugation and high product stability.
30/3/2016
— Mr. Lucas Meyer, Chemist (Germany)
The product MAC glucuronide phenol-linked SN-38 showed excellent purity and reproducibility in our tests.
26/6/2019
— Dr. Julia Martin, Senior Scientist (USA)
Reliable performance of MAC glucuronide phenol-linked SN-38 in ADC synthesis, minimal aggregation observed.
8/6/2016
— Prof. Richard Evans, Biochemistry (UK)
Smooth integration into conjugation workflow; documentation and guidance were very helpful.
10/11/2022
— Dr. Caroline Dupont, Research Chemist (France)
High stability and solubility made MAC glucuronide phenol-linked SN-38 ideal for our ADC studies.
— Mr. David Clark, Conjugation Specialist (USA)
We achieved consistent DAR values using MAC glucuronide phenol-linked SN-38. Very reliable linker.
17/12/2022
MAC glucuronide phenol-linked SN-38
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MAC glucuronide phenol-linked SN-38
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