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C-lock-GGFG-Exatecan

  CAS No.:   Cat No.: BADC-01420 4.5  

C-lock-GGFG-Exatecan is a thiol-reactive drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).

C-lock-GGFG-Exatecan

Structure of

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Category
ADC Cytotoxin with Linker
Molecular Formula
C50H46Br2FN9O9
Molecular Weight
1095.78

* For research and manufacturing use only. We do not sell to patients.

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IUPAC Name
2,3-bis(bromomethyl)-N-(2-((2-(((S)-1-((2-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)quinoxaline-6-carboxamide
InChI
InChI=1S/C50H46Br2FN9O9/c1-3-50(70)30-15-39-45-28(22-62(39)48(68)29(30)23-71-49(50)69)44-33(12-10-27-24(2)31(53)16-35(61-45)43(27)44)59-42(65)21-56-47(67)36(13-25-7-5-4-6-8-25)60-41(64)20-54-40(63)19-55-46(66)26-9-11-32-34(14-26)58-38(18-52)37(17-51)57-32/h4-9,11,14-16,33,36,70H,3,10,12-13,17-23H2,1-2H3,(H,54,63)(H,55,66)(H,56,67)(H,59,65)(H,60,64)/t33-,36-,50-/m0/s1
InChIKey
AFPZTYIOBKTBPR-RHXHCOTMSA-N

C-lock-GGFG-Exatecan, a precision chemotherapy agent, delivers Exatecan, a potent anti-cancer drug, directly to malignant cells. Explore the multifaceted applications of this innovative therapy presented in a manner rich in perplexity and burstiness.

Targeted Cancer Therapy: With a peptide link targeting cancer cells, C-lock-GGFG-Exatecan minimizes collateral damage to healthy tissues. Once at the tumor site, Exatecan is unleashed, effectively eradicating cancerous cells. This focused strategy elevates therapeutic effectiveness while mitigating the traditional side effects of chemotherapy.

Overcoming Drug Resistance: In the realm of oncology, drug resistance poses a formidable challenge. But C-lock-GGFG-Exatecan circumvents these obstacles by delivering Exatecan directly to resistant cells. This breakthrough approach holds the potential to enhance treatment outcomes for patients grappling with drug-resistant cancers.

Investigational Oncology Research: Delve into the realm of pre-clinical and clinical research with C-lock-GGFG-Exatecan as a pivotal investigative tool. Assess its efficacy and safety in diverse cancer types, such as breast, lung, and ovarian cancers. Researchers can leverage this agent to evaluate tumor responses, monitor adverse effects, and optimize dosing strategies, generating invaluable data for future clinical trials and the advancement of cancer care.

Personalized Medicine: Embrace the forefront of personalized medicine with C-lock-GGFG-Exatecan’s precise targeting mechanism. Tailor treatment plans based on the unique molecular composition of a patient’s tumor. By scrutinizing biomarkers and genetic mutations in cancer cells, oncologists can discern which individuals stand to benefit most from this therapy. This personalized paradigm strives for maximal therapeutic efficacy and enhanced patient outcomes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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