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CAS No.:
Cat No.: BADC-01288
Purity: ≥95%
4.5 
Methyltetrazine-PEG4-hydrazone-DBCO is a trifunctional ADC linker featuring methyltetrazine for IEDDA click, hydrazone for reversible conjugation, and DBCO for SPAAC, enabling versatile and controlled antibody-payload attachment.
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Methyltetrazine-PEG4-hydrazone-DBCO, a versatile chemical compound widely utilized in bioconjugation and click chemistry, offers a myriad of applications.
Bioorthogonal Chemistry: At the forefront of bioorthogonal chemistry, this compound plays a pivotal role in enabling precise and rapid labeling of biomolecules within living systems. Methyltetrazine-PEG4-hydrazone-DBCO engages in a tetrazine ligation reaction with strained alkynes like dibenzocyclooctyne (DBCO). This reaction, instrumental in live-cell imaging, empowers researchers to explore dynamic processes within cells without disrupting their inherent functions.
Drug Delivery Systems: Revolutionizing targeted drug delivery in cancer therapy, Methyltetrazine-PEG4-hydrazone-DBCO can be leveraged to design systems that selectively deliver therapeutic agents to cancer cells. By conjugating this compound with a drug, scientists achieve specific binding to cancer cells overexpressing compatible click chemistry partners. This precision enhances drug accumulation at the target site, minimizing off-target effects and optimizing treatment outcomes.
Protein Modification: In the realm of protein engineering, Methyltetrazine-PEG4-hydrazone-DBCO serves as a key player in site-specific protein modification. This capability allows for the attachment of fluorescent labels, PEGylation, or other functional groups that modulate protein activity or enhance stability. Such tailored modifications are essential for unraveling intricate protein structure-function relationships and catalyzing the development of innovative therapeutics.
Nanotechnology: Unveiling its potential in nanotechnology, this compound finds application in the surface functionalization of nanoparticles. By utilizing Methyltetrazine-PEG4-hydrazone-DBCO to anchor biomolecules onto nanoparticle surfaces, researchers enable the customization of nanoparticles for various biomedical applications. This functionalization facilitates the creation of multifunctional nanoparticles tailored for specific uses, such as targeted imaging or precise drug delivery.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01542 | Methyltetrazine-PEG5-nhs ester | 1802907-92-1 | |
| BADC-01890 | Methyltetrazine-PEG12-acid | ||
| BADC-01885 | Methyltetrazine-PEG12-NHS ester | ||
| BADC-01287 | Methyltetrazine-PEG4-aldehyde | ||
| BADC-01289 | Methyltetrazine-PEG4-oxyamine | ||
| BADC-01290 | Methyltetrazine-PEG4-SS-NHS ester | ||
| BADC-01291 | Methyltetrazine-PEG4-SS-PEG4-methyltetrazine |
Methyltetrazine-PEG4-hydrazone-DBCO
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Methyltetrazine-PEG4-hydrazone-DBCO
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