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Methyltetrazine-PEG4-oxyamine

  CAS No.:   Cat No.: BADC-01289   Purity: ≥95% 4.5  

Methyltetrazine-PEG4-oxyamine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Methyltetrazine-PEG4-oxyamine

Structure of

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Category
ADC Linker
Molecular Formula
C23H35N7O7
Molecular Weight
521.57
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Capabilities & Facilities

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Solubility
10 mm in DMSO
Shelf Life
≥ 2 years
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

Methyltetrazine-PEG4-oxyamine, a versatile bifunctional chemical compound, is a prominent player in bioconjugation and labeling techniques. Let's explore the diverse applications of Methyltetrazine-PEG4-oxyamine with intricacy and dynamism:

Bioconjugation: At the forefront of bioconjugation, Methyltetrazine-PEG4-oxyamine shines brightly thanks to its rapid reactivity with tetrazine-reactive groups through bioorthogonal click chemistry. This seamless reaction offers an efficient avenue for labeling biomolecules like proteins and antibodies, preserving their native functionality. The PEG4 spacer adds a touch of flexibility, enhancing solubility and reducing steric hindrance during conjugation.

In Vivo Imaging: Delving into in vivo imaging, Methyltetrazine-PEG4-oxyamine emerges as a vital component, linking imaging agents to biomolecules for real-time investigations of biological phenomena. The swift and selective bonding between Methyltetrazine-PEG4-oxyamine and tetrazine-modified probes ensures stable and specific labeling. This cutting-edge technology elevates target detection in live cells or animal models, propelling advancements in research, diagnosis, and therapeutic tracking.

Drug Delivery Systems: Driving innovation in targeted drug delivery, Methyltetrazine-PEG4-oxyamine takes center stage by facilitating the development of precise drug delivery systems. By conjugating therapeutic agents to targeting molecules, this compound enables efficient and selective drug delivery to specific tissues or cells. This tailored approach minimizes off-target effects and amplifies treatment efficacy, ensuring drugs are activated precisely where needed.

Protein Cross-Linking: In the realm of protein chemistry, Methyltetrazine-PEG4-oxyamine serves a critical role in protein cross-linking, pivotal for exploring protein-protein interactions. This compound fosters the creation of robust covalent bonds between diverse protein entities, preserving intricate structures for in-depth analysis.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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