Methyltetrazine-PEG12-NHS ester Catalog number: BADC-01885

Methyltetrazine-PEG12-NHS ester, a versatile chemical reagent essential for bioconjugation, finds diverse applications in various fields.

Bioconjugation Chemistry: Serving as a cornerstone in bioorthogonal labeling, Methyltetrazine-PEG12-NHS ester enables the selective and swift conjugation of biomolecules. This reagent selectively interacts with trans-cyclooctene (TCO)-modified molecules, catalyzing a highly efficient click reaction. The inclusion of a PEG12 spacer enhances solubility and flexibility, rendering it an ideal candidate for modifying proteins, peptides, and other intricate molecules.

Fluorescent Labeling: Within the realm of imaging and diagnostics, Methyltetrazine-PEG12-NHS ester facilitates the attachment of fluorescent dyes to biomolecules. By facilitating site-specific labeling of proteins or antibodies, it amplifies the sensitivity and specificity of imaging assays, particularly benefiting studies on cellular processes and the development of diagnostic tools.

Therapeutic Development: Embracing targeted drug delivery systems, Methyltetrazine-PEG12-NHS ester plays a pivotal role in conjugating therapeutic agents to targeting moieties. By facilitating precise site-specific modifications, it enables the accurate delivery of drugs to designated cells or tissues, thus enhancing therapeutic efficacy and diminishing side effects. This strategy is actively explored in the realm of anticancer and other targeted therapies.

Proteomics Research: In the vast landscape of proteomics, the utility of Methyltetrazine-PEG12-NHS ester shines in studying protein interactions and functions through the labeling of proteins with probes or affinity tags. The commendable efficiency and specificity of its conjugation chemistry streamline the capture and analysis of protein complexes, a vital component for understanding protein networks and pinpointing potential drug targets.