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NHS-Ac-N3

  Cat No.: BADC-00413   Purity: ≥98% HNMR MS 4.5  

NHS-Ac-N3 is a bioorthogonal conjugation building block that provides a bioorthogonal click handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is not clearly defined from product name; verify structure before assigning antibody conjugation chemistry. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.

NHS-Ac-N3

Structure of 824426-32-6

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Category
ADC Linker
Molecular Formula
C6H6N4O4
Molecular Weight
198.13
Shipping
Room temperature
Storage
Store at-20 °C

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
Azidoacetic acid NHS ester;(2,5-Dioxopyrrolidin-1-yl) 2-azidoacetate;
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 2-azidoacetate
SMILES
C1CC(=O)N(C1=O)OC(=O)CN=[N+]=[N-]
InChI
InChI=1S/C6H6N4O4/c7-9-8-3-6(13)14-10-4(11)1-2-5(10)12/h1-3H2
InChIKey
FENNDBOWHRZLTQ-UHFFFAOYSA-N
Appearance
White crystalline powder
Shipping
Room temperature
Storage
Store at-20 °C
Pictograms
Irritant; Acute Toxic
Signal Word
Danger

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Boc-Ser(O-propargyl)-OH (DCHA) | MTS-4-NHS | DBCO-sulfo-NHS Ester | Hydroxy-PEG2-t-butyl ester | Me-PMeOx(50)-N3 (MW 4.3kDa) | Propargyl-PEG4-thiol | PC Mal-NHS carbonate ester | Me-PMeOx(100)-N3 (MW 8.5kDa) | Exatecan hydrochloride | NHPI-PEG3-C2-PFP ester | NHS-Ac-N3
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