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m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00938 | -- | $-- | Inquiry |
mPEG10-amine, a versatile polyethylene glycol (PEG) derivative featuring an amine functional group, finds extensive utilization in diverse biotechnological and pharmaceutical realms. Here are four key applications of mPEG10-amine:
Drug Delivery: Integrating mPEG10-amine into drug delivery systems enhances the solubility and stability of therapeutic agents. By conjugating PEG chains to drugs, this compound prolongs circulation time within the bloodstream, amplifying therapeutic efficacy. Furthermore, it mitigates the immunogenicity of drugs, rendering them more amenable to repeated administrations.
Bioconjugation: Within the realm of bioconjugation, mPEG10-amine emerges as a pivotal linker molecule facilitating the attachment of biomolecules such as peptides, proteins, and antibodies. This enables the development of conjugates endowed with improved pharmacokinetic properties and targeted delivery capabilities. mPEG10-amine plays a crucial role in ensuring that conjugates maintain biological activity while minimizing non-specific interactions.
Surface Modification: Employed in the surface modification of medical devices and biosensors, mPEG10-amine contributes to reducing protein adsorption and enhancing biocompatibility. By grafting PEG chains onto surfaces, it establishes a hydrophilic barrier that impedes cell adhesion and fouling.
Nanoparticle Functionalization: Enabling the functionalization of nanoparticles, mPEG10-amine empowers their deployment in imaging, diagnostics, and therapeutic interventions. The amine group furnishes a reactive site for further chemical modifications, facilitating the attachment of targeting ligands or therapeutic agents.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
