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CAS No.: 211859-73-3
Cat No.: BADC-01067
Purity: ≥95%
4.5 
mPEG9-amine is a PEG-based spacer and synthetic linker building block used to introduce a defined hydrophilic and flexible segment into multistep conjugation designs. The PEG chain can increase molecular spacing and provide a modular connection between reactive groups without serving as a dedicated cleavage trigger. This derivative contains peg9 spacer together with terminal functionality selected for further synthesis. The available reactive group is no dedicated antibody-reactive group unless activated/functionalized; terminal functionality depends on the specific peg derivative. The opposite terminus provides terminal amine; suitable for coupling to activated carboxylates/nhs esters or for further derivatization. Coupling and deprotection conditions should be matched to the terminal groups and the intended order of assembly.
Structure of 211859-73-3
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mPEG9-amine, a versatile polyethylene glycol derivative, is prized for its chemical properties and finds widespread utility in bioconjugation endeavors. Here are four key applications of mPEG9-amine:
Drug Delivery Systems: Delving into the realm of drug delivery, mPEG9-amine emerges as a pivotal player in modifying drug molecules to heighten their solubility, stability, and bioavailability. Through the attachment of polyethylene glycol (PEG) chains to drugs, researchers can mitigate immunogenic responses and extend circulation time in the bloodstream. This innovative PEGylation approach yields enhanced therapeutic outcomes across a spectrum of pharmaceuticals encompassing anticancer agents and biologics.
Bioconjugation: Pioneering advancements in bioconjugation, mPEG9-amine assumes the role of a connector molecule, facilitating the linkage of functional groups or biomolecules to proteins, peptides, or other macromolecules. This transformative modification journey enhances the pharmacokinetic and pharmacodynamic profiles of biologics.
Surface Modification: Venturing into the domain of surface engineering, mPEG9-amine unfurls its potential in enhancing the biocompatibility of nanoparticles, biomaterials, and medical devices while concurrently curtailing non-specific binding events. The PEG chains act as guardians, erecting a protective shield that fends off unwanted protein adhesion and immune responses.
mPEG9-amine
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mPEG9-amine
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