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mPEG8-amine

  CAS No.: 869718-81-0   Cat No.: BADC-01177   Purity: ≥95% 4.5  

mPEG8-amine features a long PEG chain with an amine terminus, ideal for ADC linker synthesis. Its extended PEG8 spacer improves bioconjugate solubility, reduces aggregation, and enhances circulation stability in targeted drug delivery systems.

mPEG8-amine

Structure of 869718-81-0

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Category
ADC Linker
Molecular Formula
C17H37NO8
Molecular Weight
383.48
Shipping
Room temperature
Shipping
Store at 2-8°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
m-PEG8-amine; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-amine; mPEG8-NH2; 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine; 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine; methyl-PEG8-amine
IUPAC Name
2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES
COCCOCCOCCOCCOCCOCCOCCOCCN
InChI
InChI=1S/C17H37NO8/c1-19-4-5-21-8-9-23-12-13-25-16-17-26-15-14-24-11-10-22-7-6-20-3-2-18/h2-18H2,1H3
InChIKey
YXWBFPPGROXJLL-UHFFFAOYSA-N
Density
1.054±0.06 g/cm3 (Predicted)
Solubility
Soluble in DMSO, Water
Flash Point
213.9°C
PSA
99.86000
Appearance
Pale Yellow Oily Matter
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
448.0±40.0°C (Predicted)
Form
Solid
Biological Activity
m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

mPEG8-amine, a derivative of polyethylene glycol, boasts unique properties that make it a versatile choice for diverse biomedical and chemical applications. Explore four key applications of mPEG8-amine:

Drug Delivery: Powering the advancement of drug delivery systems, mPEG8-amine is instrumental in enhancing the solubility and stability of pharmaceutical compounds. Through the strategic conjugation of drugs with mPEG8-amine, researchers can extend their circulation time and mitigate immunogenicity, ultimately revolutionizing drug delivery efficiency and elevating therapeutic outcomes to new heights.

Bioconjugation: In the intricate domain of bioconjugation, mPEG8-amine emerges as a crucial player, facilitating the modification of proteins, peptides, and other biomolecules. Leveraging its amine functional group, mPEG8-amine enables stable covalent attachment to diverse targets, amplifying their solubility and biocompatibility. This crucial modification serves as a catalyst for enhancing the pharmacokinetics and efficacy of biologically active compounds.

Surface Modification: Delving into surface modification applications, mPEG8-amine takes center stage in the coating of medical devices and nanoparticles. By grafting mPEG8-amine onto surfaces, a hydrophilic layer is crafted, curbing protein adsorption and cell adhesion. This quality is pivotal in sculpting biocompatible surfaces that mitigate immune responses and optimize implant performance.

Diagnostics: Stepping into the realm of diagnostics, mPEG8-amine assumes a crucial role in steering the development of imaging agents and biosensors. The versatility of mPEG8-amine in conjugating with an array of probes or markers facilitates the creation of targeted diagnostics with exquisite specificity and sensitivity.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: cis-4-Hydroxy-D-proline HCl | Mp-polymer ester | Me-Tet-PEG3-NH2 | Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride | Me-Tet-PEG8-NH2 hydrochloride | MC-GGFG-NH-CH2-O-CH2-cyclopropane-COOH | L-4-trans-Hydroxyproline methyl ester hydrochloride | Methyltetrazine-DBCO | Ald-CH2-PEG5-azide | mPEG8-amine
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