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CAS No.: 854601-60-8
Cat No.: BADC-01167
Purity: ≥95%
4.5 
mPEG11-amine is a monofunctional amine-terminated PEG linker used in ADC design to enhance hydrophilicity and pharmacokinetics. Suitable for single-point conjugation and surface modification.
Structure of 854601-60-8
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mPEG11-amine, a versatile polyethylene glycol derivative, finds extensive application in the biosciences. Here are four key applications of mPEG11-amine:
Drug Delivery: Positioned at the forefront of drug delivery innovation, mPEG11-amine serves as a pivotal linker in the creation of drug delivery systems, especially in conjugating therapeutic molecules like peptides and proteins. Its inherently hydrophilic properties enhance drug solubility and stability, prolonging circulation time within the body. This optimization leads to heightened bioavailability and diminished immunogenicity, rendering mPEG11-amine indispensable in pharmaceutical endeavors.
Bioconjugation: Playing a pivotal role in biochemistry and molecular biology, mPEG11-amine emerges as a versatile reagent for diverse bioconjugation techniques. Its utility lies in attaching fluorescent dyes or antibodies to biomolecules, facilitating seamless labeling and detection in a variety of assays and imaging applications. The unique amine group enables precise and robust covalent bonding, ensuring stable conjugation conditions essential for accurate research outcomes.
Surface Modification: Embraced for surface modification strategies, mPEG11-amine contributes significantly to enhancing the biocompatibility and functionality of various materials. By coating surfaces with this compound, researchers effectively curtail protein adsorption and cell adhesion, pivotal aspects in medical device and implant technology. This transformative modification elevates material performance and longevity within biological settings, underscoring its critical role in advancing biomedical technologies.
Protein Stabilization: In the realm of protein research, mPEG11-amine emerges as a stalwart in stabilizing proteins during storage and handling procedures. Its PEG backbone acts as a shield against protein aggregation and denaturation, preserving protein activity and integrity over prolonged durations. This distinctive attribute proves invaluable in bolstering the stability of therapeutic proteins and enzymes, ensuring their optimal efficacy across diverse applications.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00938 | mPEG10-amine | 1383658-09-0 | |
| BADC-00986 | mPEG7-amine | 170572-38-0 | |
| BADC-01011 | mPEG6-amine | 184357-46-8 | |
| BADC-01648 | m-PEG12-amine | 1977493-48-3 | |
| BADC-01067 | mPEG9-amine | 211859-73-3 | |
| BADC-01115 | mPEG2-amine | 31576-51-9 | |
| BADC-01149 | mPEG3-amine | 74654-07-2 | |
| BADC-01166 | mPEG4-amine | 85030-56-4 | |
| BADC-01177 | mPEG8-amine | 869718-81-0 |
What is mPEG11-amine and its application in ADC linkers?
mPEG11-amine is a monodisperse polyethylene glycol derivative with a terminal amine group, used as a spacer or hydrophilic linker in ADCs. It enhances solubility, reduces aggregation, and allows conjugation to NHS esters or activated carboxyl groups on antibodies.
2/11/2020
We would like to know how mPEG11-amine can improve ADC properties.
The PEG11 spacer increases hydrophilicity and flexibility of ADCs, reducing steric hindrance, minimizing immunogenicity, and enhancing circulation half-life, while maintaining efficient payload delivery to target cells.
9/3/2019
Could you kindly advise which types of payloads can be attached using mPEG11-amine?
It can conjugate NHS-activated cytotoxins, peptides, and fluorophores. The terminal amine enables stable linkage formation while the PEG11 chain improves solubility and reduces aggregation in ADC formulations.
9/9/2021
Good morning! Could you please advise the recommended conjugation conditions for mPEG11-amine?
Conjugation is performed in slightly basic buffers (pH 7–8.5) or mixed organic-aqueous solvents at controlled temperatures to optimize reaction efficiency and maintain antibody and payload integrity.
3/4/2022
Good afternoon! Which supporting documents are provided to verify the identity and quality of mPEG11-amine?
BOC Sciences provides mPEG11-amine with a Certificate of Analysis, NMR spectra, and mass spectrometry data. These documents confirm molecular identity and structural integrity, supporting reproducibility and analytical verification for research applications. Full documentation is available upon request.
9/6/2022
— Dr. Matthew Green, Biochemist (UK)
mPEG11-amine offered excellent solubility and flexibility, critical for our ADC linker designs.
9/9/2021
— Ms. Anna Weber, Senior Scientist (Germany)
Consistent lot quality of mPEG11-amine enabled smooth PEGylation reactions.
9/6/2022
— Dr. Daniel Clark, ADC Development Scientist (USA)
High conjugation efficiency was achieved using mPEG11-amine.
3/4/2022
— Dr. Sophie Laurent, Medicinal Chemist (France)
mPEG11-amine minimized side products across multiple reaction protocols.
2/11/2020
— Dr. Lucas Meyer, Chemist (Germany)
Extended PEG linkers created with mPEG11-amine enhanced solubility of ADC constructs.
— Dr. Thomas Lewis, Bioconjugation Scientist (USA)
mPEG11-amine supplied by BOC Sciences facilitated efficient modification of our biomolecules. Purity was excellent, and delivery was prompt, supporting our project timeline.
9/3/2019
mPEG11-amine
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mPEG11-amine
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